Detailed information of TA system TA110933

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 356830..357348
• Replicon: chromosome
• Accession: NZ_CP032051
• Organism: Staphylococcus aureus strain O17

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: SaO17_RS01745
• Protein ID: WP_000448764.1
• Coordinates: 357046..357348 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	356830..356966 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO17_RS01705	351924..352214	+	291	WP_000179860.1	hypothetical protein	-
SaO17_RS01710	352230..354140	+	1911	WP_000429563.1	hypothetical protein	-
SaO17_RS01715	354140..355606	+	1467	WP_000067157.1	BppU family phage baseplate upper protein	-
SaO17_RS01720	355606..355995	+	390	WP_001166604.1	DUF2977 domain-containing protein	-
SaO17_RS01725	355988..356152	+	165	WP_000916020.1	XkdX family protein	-
SaO17_RS01730	356198..356497	+	300	WP_000466773.1	DUF2951 family protein	-
SaO17_RS14325	356649..356838	+	190	Protein_329	putative holin-like toxin	-
-	356830..356966	-	137	NuclAT_0	-	Antitoxin
-	356830..356966	-	137	NuclAT_0	-	Antitoxin
-	356830..356966	-	137	NuclAT_0	-	Antitoxin
-	356830..356966	-	137	NuclAT_0	-	Antitoxin
SaO17_RS01740	356885..356995	-	111	WP_070003492.1	hypothetical protein	-
SaO17_RS01745	357046..357348	+	303	WP_000448764.1	phage holin	Toxin
SaO17_RS01750	357360..358814	+	1455	WP_000930278.1	N-acetylmuramoyl-L-alanine amidase	-
SaO17_RS01760	360328..360825	+	498	WP_001803960.1	hypothetical protein	-
SaO17_RS01770	361385..362212	-	828	WP_000136028.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	315628..358814	43186

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11230.99 Da
• Isoelectric Point: 9.6587

>T110933 WP_000448764.1 NZ_CP032051:357046-357348 [Staphylococcus aureus]
METKVITRYIVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTAYKDNPTSQEGRWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T110933 NZ_CP032051:357046-357348 [Staphylococcus aureus]
ATGGAAACAAAAGTAATAACAAGATATATTGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAACAAAGGTATAAG
CCCGATACCAGTAGATGAAGAGAGTATTTCATCGATTATCTTAACAGTCATTGCTTTATACACCGCTTATAAAGACAATC
CAACATCACAAGAAGGACGCTGGGCGAATCAAAAACTAAAGAAATATAAAGCTGAAAATAAGTATAGAAAAGCAACAGGA
CAAGCGCCAATTAAAGAAGTAATGACACCTACAAATATGAATGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 137 bp

>AT110933 NZ_CP032051:c356966-356830 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTGTAGTTAAAT
GAATTTATATAATCCTCTAACCATCGTACTCGTCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin