Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 302254..302767 Replicon chromosome
Accession NZ_CP032049
Organism Rickettsia japonica strain LA4/2015

Toxin (Protein)


Gene name yoeB Uniprot ID G4KME1
Locus tag D0Z68_RS01725 Protein ID WP_014120591.1
Coordinates 302507..302767 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F3RGJ3
Locus tag D0Z68_RS01720 Protein ID WP_014013992.1
Coordinates 302254..302496 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z68_RS01700 297281..299050 - 1770 WP_024704469.1 ABC transporter ATP-binding protein/permease -
D0Z68_RS01705 299231..299500 + 270 WP_014013989.1 DUF2671 domain-containing protein -
D0Z68_RS01710 299655..301025 + 1371 WP_014120588.1 cytochrome ubiquinol oxidase subunit I -
D0Z68_RS01715 301033..302052 + 1020 WP_014120589.1 cytochrome d ubiquinol oxidase subunit II -
D0Z68_RS01720 302254..302496 + 243 WP_014013992.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0Z68_RS01725 302507..302767 + 261 WP_014120591.1 Txe/YoeB family addiction module toxin Toxin
D0Z68_RS01730 302760..303608 + 849 WP_014120592.1 glycosyltransferase family 2 protein -
D0Z68_RS01735 303685..304923 + 1239 WP_014120593.1 insulinase family protein -
D0Z68_RS01740 305077..305787 + 711 WP_014120594.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
D0Z68_RS01745 306016..307602 + 1587 WP_014120595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10254.07 Da        Isoelectric Point: 9.8788

>T110931 WP_014120591.1 NZ_CP032049:302507-302767 [Rickettsia japonica]
MYIIRYTTQAQKDAKKIVQAGLKNKVEVLLNIVSTDPWKIYPPYEKLVGDFSGCYSRRINIQHRLVCEVYKQEKVVKILR
MYTHYE

Download         Length: 261 bp

>T110931 NZ_CP032049:302507-302767 [Rickettsia japonica]
ATGTATATAATTCGTTATACTACACAAGCACAAAAAGATGCTAAGAAAATAGTGCAAGCCGGTTTAAAGAATAAAGTAGA
AGTTTTATTAAACATAGTTAGTACTGATCCTTGGAAAATTTACCCTCCATATGAAAAGCTCGTTGGTGACTTTAGCGGTT
GTTATTCAAGAAGAATTAATATTCAACATAGGTTGGTTTGTGAAGTTTACAAACAAGAAAAAGTTGTAAAAATTCTTAGA
ATGTATACGCATTATGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9405.83 Da        Isoelectric Point: 7.1617

>AT110931 WP_014013992.1 NZ_CP032049:302254-302496 [Rickettsia japonica]
MEIYNTSEARSKLYKLIDYVSDVHKPVYIKGKRNNVVIISEEDYRNMEETLYLLSIPNMHKSLIEGRAEPIAKCSDKLNW

Download         Length: 243 bp

>AT110931 NZ_CP032049:302254-302496 [Rickettsia japonica]
ATGGAAATATATAATACAAGCGAAGCAAGAAGTAAGCTTTATAAACTTATAGATTATGTTTCTGATGTACACAAACCTGT
TTATATTAAAGGTAAAAGAAATAATGTAGTTATAATTTCAGAAGAAGATTATCGTAATATGGAAGAAACTTTATATTTAT
TATCTATTCCAAATATGCATAAGTCTCTAATTGAAGGACGAGCAGAGCCTATAGCAAAGTGTAGCGATAAATTAAATTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3B7DC01

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3RGJ3

References