Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3152871..3153571 Replicon chromosome
Accession NZ_CP032011
Organism Burkholderia cepacia strain 39628

Toxin (Protein)


Gene name mqsR Uniprot ID A0A4S5DDW5
Locus tag C7S14_RS36680 Protein ID WP_060085317.1
Coordinates 3152871..3153167 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A105X490
Locus tag C7S14_RS36685 Protein ID WP_042974280.1
Coordinates 3153170..3153571 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7S14_RS36660 3149042..3149416 - 375 WP_060376069.1 hypothetical protein -
C7S14_RS36665 3149415..3150965 + 1551 WP_059484891.1 sensor domain-containing diguanylate cyclase -
C7S14_RS36670 3151209..3151484 + 276 WP_027791638.1 hypothetical protein -
C7S14_RS36675 3151727..3152767 + 1041 WP_027791639.1 succinylglutamate desuccinylase/aspartoacylase family protein -
C7S14_RS36680 3152871..3153167 + 297 WP_060085317.1 type II toxin-antitoxin system MqsR family toxin Toxin
C7S14_RS36685 3153170..3153571 + 402 WP_042974280.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
C7S14_RS36690 3153889..3154449 + 561 WP_059492207.1 GNAT family N-acetyltransferase -
C7S14_RS36695 3154506..3155453 + 948 WP_021158756.1 ABC transporter substrate-binding protein -
C7S14_RS36700 3155522..3156571 + 1050 WP_192389314.1 LLM class flavin-dependent oxidoreductase -
C7S14_RS36705 3156579..3157931 + 1353 WP_192389316.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-46)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11207.04 Da        Isoelectric Point: 8.0535

>T110929 WP_060085317.1 NZ_CP032011:3152871-3153167 [Burkholderia cepacia]
MEKRRPHCKLTLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T110929 NZ_CP032011:3152871-3153167 [Burkholderia cepacia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGACCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAACTCGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGCGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14591.86 Da        Isoelectric Point: 8.8343

>AT110929 WP_042974280.1 NZ_CP032011:3153170-3153571 [Burkholderia cepacia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRAITGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LRLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT110929 NZ_CP032011:3153170-3153571 [Burkholderia cepacia]
ATGAAATGTCCTGCATGCGGTGCCGCGAAGCTCGTCCGCGACACGCGCGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCCATCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTACGCAAGAAG
CTGAGGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCACCCCGATCTGCTCGCCGAAGTCCGGGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S5DDW5

Antitoxin

Source ID Structure
AlphaFold DB A0A105X490

References