Detailed information of TA system TA110916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1348410..1348995
• Replicon: chromosome
• Accession: NZ_CP032002
• Organism: Acinetobacter haemolyticus strain 11616

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0VLK1
• Locus tag: Ahae11616_RS06510
• Protein ID: WP_008941368.1
• Coordinates: 1348675..1348995 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Ahae11616_RS06505
• Protein ID: WP_005082538.1
• Coordinates: 1348410..1348682 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ahae11616_RS06485	1344430..1344930	+	501	WP_017396345.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
Ahae11616_RS06490	1344930..1345265	+	336	WP_008941371.1	hydroxyisourate hydrolase	-
Ahae11616_RS06495	1345313..1346689	+	1377	WP_008941370.1	purine permease	-
Ahae11616_RS06500	1346873..1348168	+	1296	WP_008941369.1	OprD family outer membrane porin	-
Ahae11616_RS06505	1348410..1348682	-	273	WP_005082538.1	helix-turn-helix domain-containing protein	Antitoxin
Ahae11616_RS06510	1348675..1348995	-	321	WP_008941368.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Ahae11616_RS06515	1349176..1350333	-	1158	WP_160124256.1	FAD-dependent urate hydroxylase HpxO	-
Ahae11616_RS06520	1350515..1351225	-	711	WP_017396344.1	FadR family transcriptional regulator	-
Ahae11616_RS06525	1351393..1352397	+	1005	WP_115736393.1	allantoicase	-
Ahae11616_RS06530	1352642..1353172	+	531	WP_008941364.1	ureidoglycolate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12140.02 Da
• Isoelectric Point: 5.8827

>T110916 WP_008941368.1 NZ_CP032002:c1348995-1348675 [Acinetobacter haemolyticus]
MLFIETSIFTKQIKELVSDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITEDDQIFMLLAY
PKSVKENLTDKETAILCQLVKEQFHG

Nucleotide

• Length: 321 bp

>T110916 NZ_CP032002:c1348995-1348675 [Acinetobacter haemolyticus]
ATGCTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAGCTTGTCTCTGATGATGAATATAGAGAACTCCAACA
AGAACTTTTAGTTCAGCCAGATAAGGGAGATCTCATTAAAAATGGTGGTGGAATTCGTAAAGTACGTTGTGCCCAAGGCA
GTAAAGGAAAAAGTGGTGGCATTCGAGTAATTTATTACTGGATCACTGAAGATGATCAGATATTTATGCTATTGGCTTAC
CCTAAATCTGTTAAAGAAAACCTAACTGATAAAGAGACCGCTATCCTATGTCAACTTGTAAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10094.53 Da
• Isoelectric Point: 8.6797

>AT110916 WP_005082538.1 NZ_CP032002:c1348682-1348410 [Acinetobacter haemolyticus]
MDNNLFDDLVASIKEAGAIKRNEVKASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT110916 NZ_CP032002:c1348682-1348410 [Acinetobacter haemolyticus]
ATGGATAATAACTTATTTGATGACCTCGTTGCTTCGATCAAAGAAGCAGGAGCTATTAAACGTAATGAAGTTAAAGCAAG
TCGAGTGACCGAGCTGACTCTTCCTGATATTAAAGAAGTTCGTGAGAAAACAGGCTTGAGCCAAACAGAATTTGCTGCAC
GTTTGCATATTAGCCCTCGTACACTTCAGAACTGGGAACAAGGCAGACGCTATCCAACAGGGCCAGCAGCAACCCTGATT
CGTATTCTAGATGCACATCCGAGCCTGATTTAA

Structures

Toxin

• AlphaFold DB: A0A372MSA3