Detailed information of TA system TA110897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1426621..1427206
• Replicon: chromosome
• Accession: NZ_CP031988
• Organism: Acinetobacter haemolyticus strain 5227

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0VLK1
• Locus tag: Ahae5227_RS06940
• Protein ID: WP_008941368.1
• Coordinates: 1426886..1427206 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: Ahae5227_RS06935
• Protein ID: WP_005082538.1
• Coordinates: 1426621..1426893 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ahae5227_RS06915	1422641..1423141	+	501	WP_017396345.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
Ahae5227_RS06920	1423141..1423476	+	336	WP_008941371.1	hydroxyisourate hydrolase	-
Ahae5227_RS06925	1423524..1424900	+	1377	WP_008941370.1	purine permease	-
Ahae5227_RS06930	1425084..1426379	+	1296	WP_008941369.1	OprD family outer membrane porin	-
Ahae5227_RS06935	1426621..1426893	-	273	WP_005082538.1	helix-turn-helix domain-containing protein	Antitoxin
Ahae5227_RS06940	1426886..1427206	-	321	WP_008941368.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Ahae5227_RS06945	1427387..1428544	-	1158	WP_008941367.1	FAD-dependent urate hydroxylase HpxO	-
Ahae5227_RS06950	1428726..1429436	-	711	WP_017396344.1	FadR family transcriptional regulator	-
Ahae5227_RS06955	1429604..1430608	+	1005	WP_115736393.1	allantoicase	-
Ahae5227_RS06960	1430853..1431383	+	531	WP_008941364.1	ureidoglycolate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12140.02 Da
• Isoelectric Point: 5.8827

>T110897 WP_008941368.1 NZ_CP031988:c1427206-1426886 [Acinetobacter haemolyticus]
MLFIETSIFTKQIKELVSDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITEDDQIFMLLAY
PKSVKENLTDKETAILCQLVKEQFHG

Nucleotide

• Length: 321 bp

>T110897 NZ_CP031988:c1427206-1426886 [Acinetobacter haemolyticus]
ATGCTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAGCTTGTCTCTGATGATGAATATAGAGAACTCCAACA
AGAACTTTTAGTTCAGCCAGATAAGGGAGATCTCATTAAAAATGGTGGTGGAATTCGTAAAGTACGTTGTGCCCAAGGCA
GTAAAGGAAAAAGTGGTGGCATTCGAGTAATTTATTACTGGATCACTGAAGATGATCAGATATTTATGCTATTGGCTTAC
CCTAAATCTGTTAAAGAAAACCTAACTGATAAAGAGACCGCTATCCTATGTCAACTTGTAAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10094.53 Da
• Isoelectric Point: 8.6797

>AT110897 WP_005082538.1 NZ_CP031988:c1426893-1426621 [Acinetobacter haemolyticus]
MDNNLFDDLVASIKEAGAIKRNEVKASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT110897 NZ_CP031988:c1426893-1426621 [Acinetobacter haemolyticus]
ATGGATAATAACTTATTTGATGACCTCGTTGCTTCGATCAAAGAAGCAGGAGCTATTAAACGTAATGAAGTTAAAGCAAG
TCGAGTGACCGAGCTGACTCTTCCTGATATTAAAGAAGTTCGTGAGAAAACAGGCTTGAGCCAAACAGAATTTGCTGCAC
GTTTGCATATTAGCCCTCGTACACTTCAGAACTGGGAACAAGGCAGACGCTATCCAACAGGGCCAGCAGCAACCCTGATT
CGTATTCTAGATGCACATCCGAGCCTGATTTAA

Structures

Toxin

• AlphaFold DB: A0A372MSA3