Detailed information of TA system TA110884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2157926..2158511
• Replicon: chromosome
• Accession: NZ_CP031979
• Organism: Acinetobacter haemolyticus strain AN4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0VLK1
• Locus tag: AhaeAN4_RS10600
• Protein ID: WP_008941368.1
• Coordinates: 2157926..2158246 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AhaeAN4_RS10605
• Protein ID: WP_005082538.1
• Coordinates: 2158239..2158511 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN4_RS10580	2153749..2154279	-	531	WP_008941364.1	ureidoglycolate lyase	-
AhaeAN4_RS10585	2154524..2155528	-	1005	WP_115736393.1	allantoicase	-
AhaeAN4_RS10590	2155696..2156406	+	711	WP_017396344.1	FadR family transcriptional regulator	-
AhaeAN4_RS10595	2156588..2157745	+	1158	WP_008941367.1	FAD-dependent urate hydroxylase HpxO	-
AhaeAN4_RS10600	2157926..2158246	+	321	WP_008941368.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AhaeAN4_RS10605	2158239..2158511	+	273	WP_005082538.1	helix-turn-helix domain-containing protein	Antitoxin
AhaeAN4_RS10610	2158753..2160048	-	1296	WP_008941369.1	OprD family outer membrane porin	-
AhaeAN4_RS10615	2160232..2161608	-	1377	WP_160132130.1	purine permease	-
AhaeAN4_RS10620	2161656..2161991	-	336	WP_008941371.1	hydroxyisourate hydrolase	-
AhaeAN4_RS10625	2161991..2162491	-	501	WP_017396345.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12140.02 Da
• Isoelectric Point: 5.8827

>T110884 WP_008941368.1 NZ_CP031979:2157926-2158246 [Acinetobacter haemolyticus]
MLFIETSIFTKQIKELVSDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITEDDQIFMLLAY
PKSVKENLTDKETAILCQLVKEQFHG

Nucleotide

• Length: 321 bp

>T110884 NZ_CP031979:2157926-2158246 [Acinetobacter haemolyticus]
ATGCTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAGCTTGTCTCTGATGATGAATATAGAGAACTCCAACA
AGAACTTTTAGTTCAGCCAGATAAGGGAGATCTCATTAAAAATGGTGGTGGAATTCGTAAAGTACGTTGTGCCCAAGGCA
GTAAAGGAAAAAGTGGTGGCATTCGAGTAATTTATTACTGGATCACTGAAGATGATCAGATATTTATGCTATTGGCTTAC
CCTAAATCTGTTAAAGAAAACCTAACTGATAAAGAGACCGCTATCCTATGTCAACTTGTAAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10094.53 Da
• Isoelectric Point: 8.6797

>AT110884 WP_005082538.1 NZ_CP031979:2158239-2158511 [Acinetobacter haemolyticus]
MDNNLFDDLVASIKEAGAIKRNEVKASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT110884 NZ_CP031979:2158239-2158511 [Acinetobacter haemolyticus]
ATGGATAATAACTTATTTGATGACCTCGTTGCTTCGATCAAAGAAGCAGGAGCTATTAAACGTAATGAAGTTAAAGCAAG
TCGAGTGACCGAGCTGACTCTTCCTGATATTAAAGAAGTTCGTGAGAAAACAGGCTTGAGCCAAACAGAATTTGCTGCAC
GTTTGCATATTAGCCCTCGTACACTTCAGAACTGGGAACAAGGCAGACGCTATCCAACAGGGCCAGCAGCAACCCTGATT
CGTATTCTAGATGCACATCCGAGCCTGATTTAA

Structures

Toxin

• AlphaFold DB: A0A372MSA3