Detailed information of TA system TA110873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1366315..1366900
• Replicon: chromosome
• Accession: NZ_CP031972
• Organism: Acinetobacter haemolyticus strain AN59

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0VLK1
• Locus tag: AhaeAN59_RS06490
• Protein ID: WP_008941368.1
• Coordinates: 1366580..1366900 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AhaeAN59_RS06485
• Protein ID: WP_005082538.1
• Coordinates: 1366315..1366587 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AhaeAN59_RS06465	1362334..1362834	+	501	WP_160126566.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
AhaeAN59_RS06470	1362834..1363169	+	336	WP_125502292.1	hydroxyisourate hydrolase	-
AhaeAN59_RS06475	1363217..1364593	+	1377	WP_160126567.1	purine permease	-
AhaeAN59_RS06480	1364778..1366073	+	1296	WP_160126568.1	OprD family outer membrane porin	-
AhaeAN59_RS06485	1366315..1366587	-	273	WP_005082538.1	helix-turn-helix domain-containing protein	Antitoxin
AhaeAN59_RS06490	1366580..1366900	-	321	WP_008941368.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AhaeAN59_RS06495	1367081..1368238	-	1158	WP_008941367.1	FAD-dependent urate hydroxylase HpxO	-
AhaeAN59_RS06500	1368420..1369130	-	711	WP_017396344.1	FadR family transcriptional regulator	-
AhaeAN59_RS06505	1369298..1370302	+	1005	WP_115736393.1	allantoicase	-
AhaeAN59_RS06510	1370547..1371077	+	531	WP_008941364.1	ureidoglycolate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12140.02 Da
• Isoelectric Point: 5.8827

>T110873 WP_008941368.1 NZ_CP031972:c1366900-1366580 [Acinetobacter haemolyticus]
MLFIETSIFTKQIKELVSDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITEDDQIFMLLAY
PKSVKENLTDKETAILCQLVKEQFHG

Nucleotide

• Length: 321 bp

>T110873 NZ_CP031972:c1366900-1366580 [Acinetobacter haemolyticus]
ATGCTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAGCTTGTCTCTGATGATGAATATAGAGAACTCCAACA
AGAACTTTTAGTTCAGCCAGATAAGGGAGATCTCATTAAAAATGGTGGTGGAATTCGTAAAGTACGTTGTGCCCAAGGCA
GTAAAGGAAAAAGTGGTGGCATTCGAGTAATTTATTACTGGATCACTGAAGATGATCAGATATTTATGCTATTGGCTTAC
CCTAAATCTGTTAAAGAAAACCTAACTGATAAAGAGACCGCTATCCTATGTCAACTTGTAAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10094.53 Da
• Isoelectric Point: 8.6797

>AT110873 WP_005082538.1 NZ_CP031972:c1366587-1366315 [Acinetobacter haemolyticus]
MDNNLFDDLVASIKEAGAIKRNEVKASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT110873 NZ_CP031972:c1366587-1366315 [Acinetobacter haemolyticus]
ATGGATAATAACTTATTTGATGACCTCGTTGCTTCGATCAAAGAAGCAGGAGCTATTAAACGTAATGAAGTTAAAGCAAG
TCGAGTGACCGAGCTGACTCTTCCTGATATTAAAGAAGTTCGTGAGAAAACAGGCTTGAGCCAAACAGAATTTGCTGCAC
GTTTGCATATTAGCCCTCGTACACTTCAGAACTGGGAACAAGGCAGACGCTATCCAACAGGGCCAGCAGCAACCCTGATT
CGTATTCTAGATGCACATCCGAGCCTGATTTAA

Structures

Toxin

• AlphaFold DB: A0A372MSA3