Detailed information of TA system TA110798

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2343826..2344197
• Replicon: chromosome
• Accession: NZ_CP031922
• Organism: Escherichia coli O26:H11 strain FWSEC0001

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: B9S25_RS11995
• Protein ID: WP_042853000.1
• Coordinates: 2344003..2344197 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2343826..2344004 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B9S25_RS11955	2339268..2339924	-	657	WP_000011658.1	carbon-nitrogen hydrolase family protein	-
B9S25_RS11960	2340026..2340256	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
B9S25_RS11965	2340395..2340769	+	375	WP_000204699.1	CopC domain-containing protein YobA	-
B9S25_RS11970	2340773..2341645	+	873	WP_000879280.1	copper homeostasis membrane protein CopD	-
B9S25_RS11975	2341658..2341999	+	342	WP_000976492.1	YebY family protein	-
B9S25_RS11980	2342392..2343468	-	1077	WP_001189091.1	phage integrase Arm DNA-binding domain-containing protein	-
B9S25_RS11985	2343434..2343715	-	282	WP_001443927.1	excisionase	-
B9S25_RS11990	2343822..2344010	-	189	WP_001356607.1	DUF1187 family protein	-
-	2343826..2344004	+	179	NuclAT_1	-	Antitoxin
-	2343826..2344004	+	179	NuclAT_1	-	Antitoxin
-	2343826..2344004	+	179	NuclAT_1	-	Antitoxin
-	2343826..2344004	+	179	NuclAT_1	-	Antitoxin
B9S25_RS11995	2344003..2344197	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
B9S25_RS12000	2344254..2345063	-	810	WP_000166317.1	recombination protein RecT	-
B9S25_RS12005	2345056..2347707	-	2652	WP_000105101.1	exodeoxyribonuclease VIII	-
B9S25_RS12010	2347806..2348081	-	276	WP_001307773.1	hypothetical protein	-
B9S25_RS12015	2348155..2348331	-	177	WP_000245534.1	hypothetical protein	-
B9S25_RS12020	2348325..2348546	-	222	WP_000560218.1	killing protein KilR	-
B9S25_RS12025	2348967..2349119	-	153	WP_001427316.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2342392..2356662	14270

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T110798 WP_042853000.1 NZ_CP031922:c2344197-2344003 [Escherichia coli O26:H11]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T110798 NZ_CP031922:c2344197-2344003 [Escherichia coli O26:H11]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACAGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT110798 NZ_CP031922:2343826-2344004 [Escherichia coli O26:H11]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin