Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 818149..818842 Replicon chromosome
Accession NZ_CP031919
Organism Escherichia coli O145:NM strain FWSEC0002

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag CCU01_RS04195 Protein ID WP_000415584.1
Coordinates 818149..818445 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CCU01_RS04200 Protein ID WP_000650107.1
Coordinates 818447..818842 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCU01_RS04160 813198..813512 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
CCU01_RS04165 813543..814124 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
CCU01_RS04170 814482..814778 + 297 WP_000912118.1 DUF2645 family protein -
CCU01_RS04175 814860..816209 - 1350 WP_000673396.1 two-component system sensor histidine kinase QseC -
CCU01_RS04180 816206..816865 - 660 WP_001221502.1 two-component system response regulator QseB -
CCU01_RS04185 817017..817409 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CCU01_RS04190 817462..817944 + 483 WP_000183497.1 GyrI-like domain-containing protein -
CCU01_RS04195 818149..818445 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
CCU01_RS04200 818447..818842 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CCU01_RS04205 818975..819685 + 711 Protein_811 ABC transporter substrate-binding protein -
CCU01_RS04210 819739..820952 + 1214 WP_136952279.1 IS3 family transposase -
CCU01_RS04215 820993..821895 + 903 Protein_813 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T110761 WP_000415584.1 NZ_CP031919:818149-818445 [Escherichia coli O145:NM]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T110761 NZ_CP031919:818149-818445 [Escherichia coli O145:NM]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGACTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT110761 WP_000650107.1 NZ_CP031919:818447-818842 [Escherichia coli O145:NM]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT110761 NZ_CP031919:818447-818842 [Escherichia coli O145:NM]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACACAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References