Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2005196..2005698 | Replicon | chromosome |
Accession | NZ_CP031910 | ||
Organism | Escherichia coli O121:H19 strain FWSEC0006 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | B9X35_RS09920 | Protein ID | WP_000767829.1 |
Coordinates | 2005444..2005698 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | B9X35_RS09915 | Protein ID | WP_001259255.1 |
Coordinates | 2005196..2005447 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
B9X35_RS09890 | 2000374..2001441 | - | 1068 | WP_000080089.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
B9X35_RS09895 | 2001441..2002511 | - | 1071 | WP_000108943.1 | histidinol-phosphate transaminase | - |
B9X35_RS09900 | 2002508..2003812 | - | 1305 | WP_000009587.1 | histidinol dehydrogenase | - |
B9X35_RS09905 | 2003818..2004717 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
B9X35_RS09910 | 2004863..2004913 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
B9X35_RS09915 | 2005196..2005447 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
B9X35_RS09920 | 2005444..2005698 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
B9X35_RS09925 | 2005781..2006605 | + | 825 | WP_000754721.1 | SDR family oxidoreductase | - |
B9X35_RS09930 | 2006651..2007580 | + | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
B9X35_RS09935 | 2007795..2007857 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
B9X35_RS09940 | 2007847..2009205 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
B9X35_RS09945 | 2009384..2010442 | + | 1059 | WP_000492305.1 | transport protein YeeE | - |
B9X35_RS09950 | 2010456..2010683 | + | 228 | WP_000985273.1 | sulfurtransferase TusA family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T110644 WP_000767829.1 NZ_CP031910:2005444-2005698 [Escherichia coli O121:H19]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T110644 NZ_CP031910:2005444-2005698 [Escherichia coli O121:H19]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT110644 WP_001259255.1 NZ_CP031910:2005196-2005447 [Escherichia coli O121:H19]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT110644 NZ_CP031910:2005196-2005447 [Escherichia coli O121:H19]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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