Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 87659..87923 Replicon plasmid unnamed18
Accession NZ_CP031903
Organism Escherichia coli O104:H4 strain FWSEC0009

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag C8200_RS26970 Protein ID WP_001387489.1
Coordinates 87771..87923 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 87659..87721 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C8200_RS26955 83761..84831 - 1071 WP_000151588.1 IncI1-type conjugal transfer protein TrbB -
C8200_RS26960 84850..86058 - 1209 WP_000121263.1 IncI1-type conjugal transfer protein TrbA -
C8200_RS26965 86365..87456 - 1092 WP_000426061.1 hypothetical protein -
- 87659..87721 - 63 NuclAT_0 - Antitoxin
- 87659..87721 - 63 NuclAT_0 - Antitoxin
- 87659..87721 - 63 NuclAT_0 - Antitoxin
- 87659..87721 - 63 NuclAT_0 - Antitoxin
C8200_RS26970 87771..87923 + 153 WP_001387489.1 Hok/Gef family protein Toxin
C8200_RS26975 87995..88246 - 252 WP_001291964.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B - 1..88545 88545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T110575 WP_001387489.1 NZ_CP031903:87771-87923 [Escherichia coli O104:H4]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T110575 NZ_CP031903:87771-87923 [Escherichia coli O104:H4]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT110575 NZ_CP031903:c87721-87659 [Escherichia coli O104:H4]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z417

Antitoxin

Download structure file

References