Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2550512..2550696 Replicon chromosome
Accession NZ_CP031890
Organism Staphylococcus aureus strain CFSAN082781

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag D1E87_RS13185 Protein ID WP_000482650.1
Coordinates 2550589..2550696 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2550512..2550572 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1E87_RS13170 2546042..2546209 - 168 WP_001790576.1 hypothetical protein -
D1E87_RS13175 2546440..2548173 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
D1E87_RS13180 2548198..2549961 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2550512..2550572 + 61 - - Antitoxin
D1E87_RS13185 2550589..2550696 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
D1E87_RS13190 2550830..2551216 - 387 WP_000779358.1 flippase GtxA -
D1E87_RS13195 2551484..2552626 + 1143 WP_149557718.1 glycerate kinase -
D1E87_RS13200 2552686..2553345 + 660 WP_000831298.1 membrane protein -
D1E87_RS13205 2553527..2554738 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
D1E87_RS13210 2554861..2555334 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T110523 WP_000482650.1 NZ_CP031890:c2550696-2550589 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T110523 NZ_CP031890:c2550696-2550589 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT110523 NZ_CP031890:2550512-2550572 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References