Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2525152..2525669 Replicon chromosome
Accession NZ_CP031888
Organism Staphylococcus aureus strain CFSAN082782

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag D1E86_RS13040 Protein ID WP_000113262.1
Coordinates 2525152..2525418 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag D1E86_RS13045 Protein ID WP_000584502.1
Coordinates 2525418..2525669 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1E86_RS13010 2520578..2521114 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
D1E86_RS13015 2521347..2522171 - 825 WP_000572040.1 formate/nitrite transporter family protein -
D1E86_RS13020 2522388..2522570 - 183 WP_000230294.1 hypothetical protein -
D1E86_RS13025 2522654..2523121 - 468 WP_000153344.1 SRPBCC domain-containing protein -
D1E86_RS13030 2523307..2524857 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
D1E86_RS13035 2525046..2525117 - 72 Protein_2468 hypothetical protein -
D1E86_RS13040 2525152..2525418 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
D1E86_RS13045 2525418..2525669 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D1E86_RS13050 2525834..2525935 - 102 WP_001791744.1 hypothetical protein -
D1E86_RS13055 2525942..2526541 - 600 WP_000162813.1 DsbA family protein -
D1E86_RS13060 2526560..2526919 - 360 WP_000819847.1 DUF4467 domain-containing protein -
D1E86_RS13065 2527174..2528424 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
D1E86_RS13070 2528521..2529252 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
D1E86_RS13075 2529249..2529968 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T110506 WP_000113262.1 NZ_CP031888:c2525418-2525152 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T110506 NZ_CP031888:c2525418-2525152 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT110506 WP_000584502.1 NZ_CP031888:c2525669-2525418 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT110506 NZ_CP031888:c2525669-2525418 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References