Detailed information of TA system TA110498

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2085776..2086075
• Replicon: chromosome
• Accession: NZ_CP031888
• Organism: Staphylococcus aureus strain CFSAN082782

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: D1E86_RS10645
• Protein ID: WP_011447039.1
• Coordinates: 2085899..2086075 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2085776..2085831 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1E86_RS10600	2081243..2081503	+	261	WP_001791826.1	hypothetical protein	-
D1E86_RS10605	2081556..2081906	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
D1E86_RS10610	2082455..2082904	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
D1E86_RS10615	2082999..2083334	-	336	Protein_2003	SH3 domain-containing protein	-
D1E86_RS10625	2083984..2084475	-	492	WP_000919350.1	staphylokinase	-
D1E86_RS10630	2084666..2085421	-	756	WP_000861038.1	CHAP domain-containing protein	-
D1E86_RS10635	2085433..2085687	-	255	WP_000611512.1	phage holin	-
D1E86_RS10640	2085739..2085846	+	108	WP_001791821.1	hypothetical protein	-
-	2085768..2085907	+	140	NuclAT_0	-	-
-	2085768..2085907	+	140	NuclAT_0	-	-
-	2085768..2085907	+	140	NuclAT_0	-	-
-	2085768..2085907	+	140	NuclAT_0	-	-
-	2085776..2085831	+	56	-	-	Antitoxin
D1E86_RS10645	2085899..2086075	-	177	WP_011447039.1	putative holin-like toxin	Toxin
D1E86_RS10650	2086225..2086521	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
D1E86_RS10655	2086579..2086866	-	288	WP_001040261.1	hypothetical protein	-
D1E86_RS10660	2086913..2087065	-	153	WP_001153681.1	hypothetical protein	-
D1E86_RS10665	2087055..2090840	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2081556..2137368	55812

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T110498 WP_011447039.1 NZ_CP031888:c2086075-2085899 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T110498 NZ_CP031888:c2086075-2085899 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT110498 NZ_CP031888:2085776-2085831 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin