Detailed information of TA system TA110495

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1924994..1925176
• Replicon: chromosome
• Accession: NZ_CP031888
• Organism: Staphylococcus aureus strain CFSAN082782

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: D1E86_RS09600
• Protein ID: WP_001801861.1
• Coordinates: 1924994..1925089 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1925117..1925176 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1E86_RS09550	1920654..1921280	+	627	Protein_1841	hypothetical protein	-
D1E86_RS09555	1921321..1921665	+	345	WP_000627551.1	DUF3969 family protein	-
D1E86_RS09560	1921763..1922314	+	552	WP_000414205.1	hypothetical protein	-
D1E86_RS09565	1922532..1923173	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
D1E86_RS09570	1923287..1923472	-	186	WP_000809857.1	hypothetical protein	-
D1E86_RS09575	1923474..1923650	-	177	WP_000375476.1	hypothetical protein	-
D1E86_RS09580	1923661..1924044	-	384	WP_149557713.1	hypothetical protein	-
D1E86_RS09590	1924648..1924791	-	144	WP_001549059.1	transposase	-
D1E86_RS09600	1924994..1925089	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1925117..1925176	-	60	-	-	Antitoxin
D1E86_RS09605	1925212..1925313	+	102	WP_001791893.1	hypothetical protein	-
D1E86_RS09610	1925291..1925467	-	177	Protein_1851	transposase	-
D1E86_RS09615	1925661..1926038	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T110495 WP_001801861.1 NZ_CP031888:1924994-1925089 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T110495 NZ_CP031888:1924994-1925089 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT110495 NZ_CP031888:c1925176-1925117 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin