Detailed information of TA system TA110488

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1982038..1982345
• Replicon: chromosome
• Accession: NZ_CP031886
• Organism: Staphylococcus aureus strain CFSAN082783

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: D1E88_RS09945
• Protein ID: WP_011447039.1
• Coordinates: 1982169..1982345 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1982038..1982177 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1E88_RS09900	1977378..1977638	+	261	WP_001791826.1	hypothetical protein	-
D1E88_RS09905	1977691..1978041	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
D1E88_RS09910	1978725..1979174	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
D1E88_RS09915	1979269..1979604	-	336	Protein_1878	SH3 domain-containing protein	-
D1E88_RS09925	1980254..1980745	-	492	WP_000919350.1	staphylokinase	-
D1E88_RS09930	1980936..1981691	-	756	WP_000861038.1	CHAP domain-containing protein	-
D1E88_RS09935	1981703..1981957	-	255	WP_000611512.1	phage holin	-
D1E88_RS09940	1982009..1982116	+	108	WP_001791821.1	hypothetical protein	-
-	1982038..1982177	+	140	NuclAT_0	-	Antitoxin
-	1982038..1982177	+	140	NuclAT_0	-	Antitoxin
-	1982038..1982177	+	140	NuclAT_0	-	Antitoxin
-	1982038..1982177	+	140	NuclAT_0	-	Antitoxin
D1E88_RS09945	1982169..1982345	-	177	WP_011447039.1	putative holin-like toxin	Toxin
D1E88_RS09950	1982495..1982791	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
D1E88_RS09955	1982849..1983136	-	288	WP_001040261.1	hypothetical protein	-
D1E88_RS09960	1983183..1983335	-	153	WP_001153681.1	hypothetical protein	-
D1E88_RS09965	1983325..1987110	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL	1973861..2029198	55337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T110488 WP_011447039.1 NZ_CP031886:c1982345-1982169 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T110488 NZ_CP031886:c1982345-1982169 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT110488 NZ_CP031886:1982038-1982177 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin