Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1606479..1607212 Replicon chromosome
Accession NZ_CP031848
Organism Marinobacter sp. Arc7-DN-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D0851_RS07595 Protein ID WP_117620321.1
Coordinates 1606901..1607212 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D0851_RS07590 Protein ID WP_117618092.1
Coordinates 1606479..1606895 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0851_RS07575 1601857..1602981 + 1125 WP_117618089.1 alanine dehydrogenase -
D0851_RS07580 1603080..1604465 + 1386 WP_117618090.1 sodium:alanine symporter family protein -
D0851_RS07585 1604675..1606477 - 1803 WP_117618091.1 DEAD/DEAH box helicase -
D0851_RS07590 1606479..1606895 - 417 WP_117618092.1 transcriptional regulator Antitoxin
D0851_RS07595 1606901..1607212 - 312 WP_117620321.1 type II toxin-antitoxin system HigB family toxin Toxin
D0851_RS07605 1607657..1608217 + 561 WP_117618093.1 hypothetical protein -
D0851_RS07610 1608419..1608763 + 345 WP_117618094.1 SEC-C domain-containing protein -
D0851_RS07615 1608793..1609227 + 435 WP_117620322.1 DUF3010 family protein -
D0851_RS07620 1609355..1610650 - 1296 WP_205422288.1 mechanosensitive ion channel -
D0851_RS07625 1610745..1611056 - 312 WP_117618096.1 helix-turn-helix transcriptional regulator -
D0851_RS07630 1611071..1611424 - 354 WP_117618097.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(7-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12572.20 Da        Isoelectric Point: 9.9275

>T110344 WP_117620321.1 NZ_CP031848:c1607212-1606901 [Marinobacter sp. Arc7-DN-1]
VHIISRKPFSDAARQFPNDREALVNTYTTLRYGRFETPDQLRQVFPSLDNFKYRDKWWVIDIGGNNLRLIAFIEFRDNRM
YVKHICSHADYDRLTDKYRRNRE

Download         Length: 312 bp

>T110344 NZ_CP031848:c1607212-1606901 [Marinobacter sp. Arc7-DN-1]
GTGCACATTATTTCAAGAAAGCCGTTCAGTGATGCGGCTAGGCAGTTTCCCAATGACCGGGAGGCTCTGGTAAATACCTA
CACCACGTTGCGTTATGGACGGTTTGAAACACCTGATCAGCTGCGCCAGGTGTTCCCGTCCCTGGACAATTTCAAATACC
GGGACAAATGGTGGGTTATCGACATTGGCGGCAACAATTTACGGCTGATCGCCTTCATTGAGTTTCGTGATAATCGCATG
TATGTGAAACACATTTGCAGCCACGCCGATTACGACCGGCTGACTGACAAATACCGTCGCAATAGGGAGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15273.49 Da        Isoelectric Point: 4.5822

>AT110344 WP_117618092.1 NZ_CP031848:c1606895-1606479 [Marinobacter sp. Arc7-DN-1]
MLSPAFVEIREALARVPYVAHIETQDDYERALELMDQLVDDYDANKLLIEILAVSIERWEDQAAEFSDFNAAVAETDRGI
AVLKTLMAQHGLGVADLPELGSKGNVSKILNGAEGKKLTRKHMEALGKRFGVSPVLFF

Download         Length: 417 bp

>AT110344 NZ_CP031848:c1606895-1606479 [Marinobacter sp. Arc7-DN-1]
ATGTTATCGCCTGCTTTTGTTGAGATCAGAGAAGCGCTGGCCCGGGTGCCTTATGTGGCCCACATTGAGACCCAGGATGA
CTATGAGCGAGCGTTGGAGCTGATGGACCAACTGGTGGACGACTACGACGCCAATAAACTGTTAATTGAGATTCTGGCTG
TCAGTATTGAGCGCTGGGAGGACCAGGCTGCAGAGTTTTCCGACTTCAATGCCGCTGTTGCAGAAACGGACAGGGGGATT
GCTGTACTGAAAACCCTGATGGCTCAACACGGTCTTGGGGTTGCTGATCTGCCGGAGTTGGGCTCAAAGGGCAATGTGAG
CAAGATTCTCAATGGTGCTGAAGGTAAAAAACTGACCCGCAAACACATGGAAGCCCTCGGCAAGCGGTTTGGGGTGTCTC
CGGTACTGTTTTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References