Detailed information of TA system TA110343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1594080..1594549
• Replicon: chromosome
• Accession: NZ_CP031848
• Organism: Marinobacter sp. Arc7-DN-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: D0851_RS07500
• Protein ID: WP_117618078.1
• Coordinates: 1594080..1594262 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D0851_RS07505
• Protein ID: WP_117618079.1
• Coordinates: 1594259..1594549 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0851_RS07465	1589472..1589900	-	429	WP_117618074.1	DUF4399 domain-containing protein	-
D0851_RS07470	1589991..1590425	-	435	WP_162893696.1	thioredoxin family protein	-
D0851_RS07475	1590351..1590536	+	186	Protein_1444	propionyl-CoA--succinate CoA transferase	-
D0851_RS07480	1590694..1591998	-	1305	WP_117618076.1	TRAP transporter large permease	-
D0851_RS20305	1592423..1593109	-	687	Protein_1446	TRAP transporter substrate-binding protein DctP	-
D0851_RS07490	1593211..1593708	+	498	WP_117618077.1	DUF2780 domain-containing protein	-
D0851_RS07500	1594080..1594262	+	183	WP_117618078.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0851_RS07505	1594259..1594549	+	291	WP_117618079.1	helix-turn-helix domain-containing protein	Antitoxin
D0851_RS07510	1594612..1595055	-	444	WP_117618080.1	cupin domain-containing protein	-
D0851_RS07520	1595576..1595960	+	385	Protein_1451	hypothetical protein	-
D0851_RS07530	1596379..1597275	-	897	WP_117618082.1	SRPBCC family protein	-
D0851_RS07535	1597396..1597680	+	285	WP_117618083.1	DUF3175 domain-containing protein	-
D0851_RS07545	1598110..1599102	+	993	WP_117618084.1	MBL fold metallo-hydrolase	-
D0851_RS07550	1599109..1599306	-	198	Protein_1455	cold shock domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-55)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-81)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6974.39 Da
• Isoelectric Point: 10.5367

>T110343 WP_117618078.1 NZ_CP031848:1594080-1594262 [Marinobacter sp. Arc7-DN-1]
MGDELFEIRAKAKEGIGRGIFCYMQGKRIIILHAFVKKDQKIPKKDLELAKERLKEVKKS

Nucleotide

• Length: 183 bp

>T110343 NZ_CP031848:1594080-1594262 [Marinobacter sp. Arc7-DN-1]
TTGGGTGACGAGCTTTTCGAGATCCGCGCAAAAGCCAAAGAAGGAATCGGGAGAGGAATCTTCTGCTACATGCAGGGCAA
GCGAATTATAATTCTGCATGCCTTTGTAAAGAAGGATCAGAAAATACCGAAGAAAGACCTGGAACTCGCGAAAGAGCGAT
TGAAGGAGGTCAAAAAATCATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10855.27 Da
• Isoelectric Point: 6.3649

>AT110343 WP_117618079.1 NZ_CP031848:1594259-1594549 [Marinobacter sp. Arc7-DN-1]
MSFEQFKQKALKDPEVRQEYDALEEEFSLIDQLISMRTKAGLTQEDVAKKLGTNKSNISRLERGRSNPSWGTLSKYAAAC
GFRVKLEAVEDDRALA

Nucleotide

• Length: 291 bp

>AT110343 NZ_CP031848:1594259-1594549 [Marinobacter sp. Arc7-DN-1]
ATGAGTTTCGAACAGTTTAAGCAGAAAGCGCTGAAAGATCCCGAGGTTCGTCAGGAATACGATGCCCTCGAGGAAGAATT
CAGCCTGATCGACCAGCTGATTTCCATGAGGACGAAAGCGGGCCTCACCCAGGAAGATGTCGCGAAGAAACTCGGAACGA
ACAAAAGCAACATCTCCAGGCTTGAGCGTGGCCGTAGCAATCCAAGCTGGGGAACGCTCAGCAAATATGCCGCAGCCTGT
GGTTTTCGGGTAAAGCTGGAAGCGGTTGAAGACGACCGGGCATTAGCCTGA