Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1424428..1425044 Replicon chromosome
Accession NZ_CP031848
Organism Marinobacter sp. Arc7-DN-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D0851_RS06620 Protein ID WP_117617925.1
Coordinates 1424763..1425044 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag D0851_RS06615 Protein ID WP_205422275.1
Coordinates 1424428..1424754 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0851_RS06595 1420091..1420747 - 657 WP_117617921.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase -
D0851_RS06600 1420980..1421645 + 666 WP_117617922.1 hypothetical protein -
D0851_RS06605 1421642..1422415 - 774 WP_117617923.1 TSUP family transporter -
D0851_RS06610 1422513..1424390 + 1878 WP_117617924.1 methyl-accepting chemotaxis protein -
D0851_RS06615 1424428..1424754 - 327 WP_205422275.1 HigA family addiction module antidote protein Antitoxin
D0851_RS06620 1424763..1425044 - 282 WP_117617925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0851_RS06625 1425242..1425331 - 90 Protein_1279 prevent-host-death family protein -
D0851_RS06630 1425418..1425819 - 402 WP_205422276.1 hypothetical protein -
D0851_RS06635 1426016..1426288 + 273 WP_117617926.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
D0851_RS06640 1426269..1426541 + 273 WP_117617927.1 Txe/YoeB family addiction module toxin -
D0851_RS06645 1426644..1426901 - 258 WP_117617928.1 DUF2931 family protein -
D0851_RS20300 1426916..1427377 - 462 WP_205422277.1 transposase -
D0851_RS06655 1427758..1428942 + 1185 WP_117617929.1 YncE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(15-93)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10771.17 Da        Isoelectric Point: 8.4955

>T110342 WP_117617925.1 NZ_CP031848:c1425044-1424763 [Marinobacter sp. Arc7-DN-1]
MIKSFADKRTQELYSKGKSKRFPADIAPRAARKLEYVNLAEQLEDLKVPPGNRLHPPCGKRHGQHSIAINDQWRICFRFD
DGDAYEVEVSDYH

Download         Length: 282 bp

>T110342 NZ_CP031848:c1425044-1424763 [Marinobacter sp. Arc7-DN-1]
ATGATCAAATCCTTCGCTGACAAACGAACTCAAGAGCTGTACTCCAAAGGTAAGTCAAAAAGGTTTCCTGCGGATATCGC
TCCGAGAGCTGCCAGAAAACTTGAATACGTCAATCTGGCTGAACAGCTGGAGGACTTGAAAGTGCCGCCCGGCAATCGCC
TTCACCCACCTTGCGGAAAGAGGCATGGGCAGCACTCGATTGCAATAAATGATCAGTGGCGTATCTGTTTTCGTTTTGAC
GATGGCGATGCGTACGAGGTCGAAGTGAGTGACTACCACTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12118.90 Da        Isoelectric Point: 7.2052

>AT110342 WP_205422275.1 NZ_CP031848:c1424754-1424428 [Marinobacter sp. Arc7-DN-1]
MTMAIPISNTTGMQRKPTHPGEMLREDFLPDYDLTVTGLAESLGVSRQSVNELLRERRAVSPEMALRLARLFGNSPEFWL
NAQRAVDLWTAAQSVKEEVSRIKPLHAA

Download         Length: 327 bp

>AT110342 NZ_CP031848:c1424754-1424428 [Marinobacter sp. Arc7-DN-1]
ATGACTATGGCTATTCCTATTTCTAACACTACCGGCATGCAGCGCAAGCCGACCCATCCTGGTGAAATGCTGAGAGAGGA
TTTTTTGCCGGACTATGATCTGACGGTTACAGGGCTGGCTGAGTCTCTGGGTGTCTCTCGTCAGTCAGTTAATGAACTGT
TGCGTGAACGCCGTGCTGTCAGCCCTGAAATGGCACTTCGGCTGGCACGTTTGTTTGGCAACTCTCCAGAGTTTTGGCTG
AATGCACAGCGCGCTGTTGATTTGTGGACGGCGGCTCAATCGGTCAAGGAGGAGGTTAGTCGGATTAAGCCGTTGCATGC
TGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References