Detailed information of TA system TA110341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1197639..1198296
• Replicon: chromosome
• Accession: NZ_CP031848
• Organism: Marinobacter sp. Arc7-DN-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: D0851_RS05590
• Protein ID: WP_117617735.1
• Coordinates: 1197943..1198296 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D0851_RS05585
• Protein ID: WP_117617734.1
• Coordinates: 1197639..1197941 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0851_RS05545	1192783..1193247	-	465	WP_117620299.1	hypothetical protein	-
D0851_RS05555	1193891..1194082	-	192	WP_117617728.1	DUF2283 domain-containing protein	-
D0851_RS05560	1194079..1194339	-	261	WP_117617729.1	DUF4258 domain-containing protein	-
D0851_RS05565	1194489..1195850	+	1362	WP_117617730.1	MBL fold metallo-hydrolase	-
D0851_RS05570	1195952..1196992	+	1041	WP_117617731.1	nucleotidyltransferase domain-containing protein	-
D0851_RS05575	1197050..1197208	-	159	WP_117617732.1	CcdB family protein	-
D0851_RS05580	1197205..1197459	-	255	WP_117617733.1	type II toxin-antitoxin system CcdA family antitoxin	-
D0851_RS05585	1197639..1197941	-	303	WP_117617734.1	XRE family transcriptional regulator	Antitoxin
D0851_RS05590	1197943..1198296	-	354	WP_117617735.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0851_RS05595	1198444..1199409	+	966	WP_117617736.1	transposase	-
D0851_RS05600	1199756..1200754	-	999	WP_117617737.1	Rpn family recombination-promoting nuclease/putative transposase	-
D0851_RS05605	1200906..1201472	+	567	Protein_1076	transposase	-
D0851_RS05610	1201805..1202425	-	621	WP_162893690.1	hypothetical protein	-
D0851_RS05620	1202807..1203235	-	429	WP_117617740.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (20-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13351.14 Da
• Isoelectric Point: 7.4214

>T110341 WP_117617735.1 NZ_CP031848:c1198296-1197943 [Marinobacter sp. Arc7-DN-1]
MWNIKTTHRFDDWYHSLGDADRENVLAAILVLKEKGPMLSRPHADSVYGSEHSNMKELRVQSKGRPIRAFFAFDPSRTGI
ILCAGEKSGKDKRFYDEMIPVADREFTAHLEELKGGN

Nucleotide

• Length: 354 bp

>T110341 NZ_CP031848:c1198296-1197943 [Marinobacter sp. Arc7-DN-1]
ATGTGGAATATTAAAACAACTCACCGGTTTGACGATTGGTACCACTCGCTTGGCGATGCGGACAGAGAGAATGTCCTGGC
GGCGATACTGGTGTTAAAAGAGAAAGGTCCGATGCTATCCCGGCCACACGCCGACAGCGTTTATGGATCTGAACATAGCA
ATATGAAAGAGCTTAGGGTTCAGAGCAAAGGCAGACCCATTCGGGCGTTTTTTGCATTTGATCCATCTCGCACTGGCATA
ATTCTCTGTGCTGGCGAGAAATCGGGTAAAGACAAACGGTTTTACGATGAGATGATTCCAGTGGCAGATCGAGAATTCAC
CGCCCATTTGGAAGAGCTCAAGGGAGGCAATTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11011.85 Da
• Isoelectric Point: 9.7252

>AT110341 WP_117617734.1 NZ_CP031848:c1197941-1197639 [Marinobacter sp. Arc7-DN-1]
MANSLDALLANEKPDVVRRAQIKADRILLEIRLSEVRALLQKTQKDLAEAMGVTQPTIANMEKAGKDLKLSSIKRYVESA
GAKVRLDIELPDGTHHAIPL

Nucleotide

• Length: 303 bp

>AT110341 NZ_CP031848:c1197941-1197639 [Marinobacter sp. Arc7-DN-1]
ATGGCGAATTCTTTGGACGCACTGCTGGCTAATGAAAAGCCAGACGTTGTCAGGCGAGCGCAGATCAAAGCAGATCGCAT
TCTTTTGGAGATTCGACTCAGTGAAGTGCGTGCTTTGTTGCAGAAAACCCAGAAAGATTTGGCGGAAGCCATGGGTGTAA
CCCAGCCTACGATCGCGAATATGGAAAAAGCCGGTAAAGACTTGAAGCTATCATCCATTAAACGATACGTCGAGAGTGCG
GGTGCGAAAGTCCGTTTGGATATTGAGCTTCCTGACGGAACTCATCACGCCATTCCGCTTTGA