Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1192074..1192664 Replicon chromosome
Accession NZ_CP031848
Organism Marinobacter sp. Arc7-DN-1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag D0851_RS05540 Protein ID WP_117620298.1
Coordinates 1192386..1192664 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D0851_RS05535 Protein ID WP_205422274.1
Coordinates 1192074..1192373 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0851_RS05510 1188235..1189596 + 1362 WP_117617724.1 MBL fold metallo-hydrolase -
D0851_RS05515 1189653..1189979 - 327 WP_117617725.1 nucleotidyltransferase domain-containing protein -
D0851_RS05520 1189966..1190394 - 429 WP_117617726.1 nucleotidyltransferase substrate binding protein -
D0851_RS05525 1190709..1191152 - 444 WP_117617727.1 pilin -
D0851_RS05530 1191470..1191898 - 429 WP_117620296.1 hypothetical protein -
D0851_RS05535 1192074..1192373 - 300 WP_205422274.1 HigA family addiction module antidote protein Antitoxin
D0851_RS05540 1192386..1192664 - 279 WP_117620298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0851_RS05545 1192783..1193247 - 465 WP_117620299.1 hypothetical protein -
D0851_RS05555 1193891..1194082 - 192 WP_117617728.1 DUF2283 domain-containing protein -
D0851_RS05560 1194079..1194339 - 261 WP_117617729.1 DUF4258 domain-containing protein -
D0851_RS05565 1194489..1195850 + 1362 WP_117617730.1 MBL fold metallo-hydrolase -
D0851_RS05570 1195952..1196992 + 1041 WP_117617731.1 nucleotidyltransferase domain-containing protein -
D0851_RS05575 1197050..1197208 - 159 WP_117617732.1 CcdB family protein -
D0851_RS05580 1197205..1197459 - 255 WP_117617733.1 type II toxin-antitoxin system CcdA family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-89)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10614.17 Da        Isoelectric Point: 9.6804

>T110340 WP_117620298.1 NZ_CP031848:c1192664-1192386 [Marinobacter sp. Arc7-DN-1]
MIKSFRCKDTETLFKTGKSRRFSAVKAAAERKLIILTAAEALEDLKSPPGNRLEALAGDREGQYSIRINRQWRVCFRWTK
EGPEDVEIVDYH

Download         Length: 279 bp

>T110340 NZ_CP031848:c1192664-1192386 [Marinobacter sp. Arc7-DN-1]
ATGATTAAGAGCTTCCGTTGTAAAGACACTGAAACCTTGTTCAAGACCGGGAAAAGCCGGCGATTTTCGGCAGTCAAGGC
TGCTGCTGAGCGCAAGCTTATTATCCTGACGGCAGCGGAAGCCTTAGAGGATTTGAAATCTCCGCCCGGCAATCGCCTGG
AAGCGCTCGCCGGAGATCGGGAAGGCCAATACAGCATTCGAATTAATCGCCAGTGGAGGGTGTGCTTCCGGTGGACCAAA
GAAGGGCCGGAAGATGTTGAGATTGTTGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11144.86 Da        Isoelectric Point: 9.8875

>AT110340 WP_205422274.1 NZ_CP031848:c1192373-1192074 [Marinobacter sp. Arc7-DN-1]
MVSNGMRPIHPGEILREEYLEPLGMSVNALAGALHVPATRMNEIVRENRGITADTALRLARYFGTSERFWLNLQIEFELR
RAQISKAAQVAKEVQPRAA

Download         Length: 300 bp

>AT110340 NZ_CP031848:c1192373-1192074 [Marinobacter sp. Arc7-DN-1]
ATGGTATCCAATGGCATGCGTCCCATTCACCCGGGGGAAATTCTTCGGGAAGAGTATCTGGAACCGTTGGGCATGAGCGT
TAATGCGTTGGCTGGAGCGCTTCACGTTCCGGCTACCCGGATGAACGAGATTGTTCGCGAAAATCGCGGTATCACTGCAG
ACACGGCGTTGCGCCTGGCTCGTTACTTCGGCACCAGCGAGCGCTTTTGGCTAAACTTGCAAATCGAGTTTGAGTTGCGC
AGAGCTCAAATCAGCAAAGCCGCGCAAGTGGCTAAAGAAGTTCAACCTCGGGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References