Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 716749..717343 Replicon chromosome
Accession NZ_CP031843
Organism Bartonella kosoyi strain Tel Aviv

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag D1093_RS02930 Protein ID WP_174767392.1
Coordinates 716749..717030 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag D1093_RS02935 Protein ID WP_120100579.1
Coordinates 717047..717343 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1093_RS02905 713177..714289 - 1113 WP_120100570.1 phage tail protein -
D1093_RS02910 714289..715116 - 828 WP_120100572.1 baseplate J/gp47 family protein -
D1093_RS02915 715113..715454 - 342 WP_120100574.1 GPW/gp25 family protein -
D1093_RS02920 715451..716140 - 690 WP_120100576.1 phage baseplate assembly protein V -
D1093_RS02925 716121..716663 - 543 WP_120102300.1 hypothetical protein -
D1093_RS02930 716749..717030 + 282 WP_174767392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1093_RS02935 717047..717343 + 297 WP_120100579.1 HigA family addiction module antidote protein Antitoxin
D1093_RS02940 717390..717668 - 279 WP_120100581.1 hypothetical protein -
D1093_RS02945 717665..718405 - 741 WP_120100582.1 phage regulatory protein/antirepressor Ant -
D1093_RS02955 718736..719092 - 357 WP_120100584.1 hypothetical protein -
D1093_RS02960 719094..720170 - 1077 WP_120100585.1 major capsid protein -
D1093_RS02965 720183..720550 - 368 Protein_559 head decoration protein -
D1093_RS02970 720547..720891 - 345 WP_120102301.1 hypothetical protein -
D1093_RS02975 720810..721877 - 1068 WP_120100587.1 S49 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 686506..811189 124683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10822.51 Da        Isoelectric Point: 9.5600

>T110312 WP_174767392.1 NZ_CP031843:716749-717030 [Bartonella kosoyi]
VIESFVDKRCKDLLEGKTPKGFPATLVRIAQRKLFMLDKAVDLKDLRSPPGNHLEALKGERKGQYSIRINNQFRLCFEWR
TNGAYEVEIVDYH

Download         Length: 282 bp

>T110312 NZ_CP031843:716749-717030 [Bartonella kosoyi]
GTGATTGAATCTTTTGTGGATAAGCGGTGTAAAGATCTTTTAGAAGGCAAGACGCCCAAAGGTTTTCCTGCAACATTGGT
ACGCATAGCACAAAGAAAATTGTTTATGCTCGATAAAGCAGTTGATCTTAAAGATTTGCGCAGTCCTCCAGGAAATCATT
TAGAAGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATTAATAACCAGTTTCGTCTTTGTTTTGAATGGCGT
ACTAATGGTGCCTATGAAGTTGAAATTGTAGATTATCATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11237.90 Da        Isoelectric Point: 5.1372

>AT110312 WP_120100579.1 NZ_CP031843:717047-717343 [Bartonella kosoyi]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPITPDTALRLASFFDTTAEFWLNMQAAYDVHIL
QAEKADEFAKINKFECTI

Download         Length: 297 bp

>AT110312 NZ_CP031843:717047-717343 [Bartonella kosoyi]
ATGAAAAATTATATTGCAATACATCCTGGAGAAATTTTACGGGAGGAATATTTAAAAGAATATGCTCTTTCTGCTTATGC
CCTTGCAAAAGCATTGAATGTTCCACGCACGAGGATAGAACGTATTGTTGCGGAAAATAGTCCAATAACTCCTGATACGG
CTCTCAGACTGGCTTCTTTTTTTGATACGACAGCTGAATTTTGGCTTAATATGCAAGCTGCTTATGATGTTCATATTTTA
CAAGCCGAAAAAGCAGATGAATTTGCCAAAATTAATAAATTTGAATGTACAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References