Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4663079..4663669 Replicon chromosome
Accession NZ_CP031841
Organism Breoghania sp. L-A4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D1F64_RS21305 Protein ID WP_117414058.1
Coordinates 4663079..4663360 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D1F64_RS21310 Protein ID WP_117414059.1
Coordinates 4663370..4663669 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1F64_RS21280 4659615..4660682 + 1068 WP_117414769.1 hypothetical protein -
D1F64_RS23650 4660682..4660846 + 165 WP_162901697.1 hypothetical protein -
D1F64_RS21285 4660858..4661043 + 186 Protein_4271 RNA polymerase sigma factor RpoD -
D1F64_RS21290 4661183..4661644 + 462 WP_117414055.1 hypothetical protein -
D1F64_RS21295 4661638..4662471 + 834 WP_117414056.1 DUF930 domain-containing protein -
D1F64_RS21300 4662596..4662985 + 390 WP_117414057.1 DoxX family protein -
D1F64_RS21305 4663079..4663360 + 282 WP_117414058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1F64_RS21310 4663370..4663669 + 300 WP_117414059.1 HigA family addiction module antidote protein Antitoxin
D1F64_RS21315 4663838..4664188 + 351 WP_117414060.1 metalloregulator ArsR/SmtB family transcription factor -
D1F64_RS21320 4664185..4665270 + 1086 WP_117414061.1 permease -
D1F64_RS21325 4665282..4666163 + 882 WP_117414062.1 transglutaminase-like domain-containing protein -
D1F64_RS21330 4666214..4666498 + 285 WP_117414063.1 SelT/SelW/SelH family protein -
D1F64_RS21335 4666656..4667579 + 924 WP_117414064.1 DMT family transporter -
D1F64_RS21340 4667771..4668028 + 258 WP_162901698.1 DUF1344 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-96)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.58 Da        Isoelectric Point: 11.0696

>T110309 WP_117414058.1 NZ_CP031841:4663079-4663360 [Breoghania sp. L-A4]
MIKSFADKETRRVFERRRSRRLPENIQRRAQIKLAQINAATVLDDLRVPPSNHLESLKGSRAGQHSIRINVQWRICFQWR
DGHACDVEIVDYH

Download         Length: 282 bp

>T110309 NZ_CP031841:4663079-4663360 [Breoghania sp. L-A4]
ATGATCAAGAGTTTCGCGGACAAGGAAACCCGGCGGGTTTTCGAGCGGCGGCGCTCCCGTCGTTTGCCGGAAAATATTCA
GCGGCGGGCGCAGATAAAACTCGCACAGATCAACGCGGCGACTGTTCTCGACGATTTGCGCGTGCCGCCGAGCAACCATC
TGGAAAGCCTCAAGGGCAGCCGCGCCGGGCAACATTCGATCCGCATCAACGTGCAATGGCGGATTTGCTTCCAGTGGCGC
GACGGTCACGCCTGCGACGTCGAAATCGTCGACTATCATTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11219.87 Da        Isoelectric Point: 5.7185

>AT110309 WP_117414059.1 NZ_CP031841:4663370-4663669 [Breoghania sp. L-A4]
MSDDRFAPIHPGEILREEYLPEFGLTAYGLAKALHVPRDRIEALVRERRGITADTALRLGRFFGQTPDFWLNLQTQYDLE
VARLKLGADLEGIAPLRVA

Download         Length: 300 bp

>AT110309 NZ_CP031841:4663370-4663669 [Breoghania sp. L-A4]
ATGAGCGACGATCGATTTGCACCGATCCACCCAGGCGAAATCCTGCGTGAGGAGTATCTTCCGGAATTCGGCTTGACGGC
CTACGGCCTTGCGAAGGCCCTGCACGTTCCGCGCGACCGTATTGAAGCGCTGGTGCGGGAAAGGCGCGGCATCACCGCGG
ACACGGCGCTGCGTCTCGGCCGCTTCTTTGGTCAGACGCCTGACTTCTGGCTCAACCTGCAGACGCAGTACGACCTCGAG
GTCGCGCGGTTGAAGCTTGGCGCGGATCTTGAGGGGATCGCGCCGCTTCGCGTCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References