Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4663079..4663669 Replicon chromosome
Accession NZ_CP031841
Organism Breoghania sp. L-A4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D1F64_RS21305 Protein ID WP_117414058.1
Coordinates 4663079..4663360 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D1F64_RS21310 Protein ID WP_117414059.1
Coordinates 4663370..4663669 (+) Length 100 a.a.

Genomic Context

D1F64_RS21280D1F64_RS23650D1F64_RS21285D1F64_RS21290D1F64_RS21295D1F64_RS21300D1F64_RS21305D1F64_RS21310D1F64_RS21315D1F64_RS21320D1F64_RS21325D1F64_RS21330D1F64_RS21335D1F64_RS21340
Location: 4659615..4660682 (1068 bp)
Type: Others
Protein ID: WP_117414769.1
Location: 4660682..4660846 (165 bp)
Type: Others
Protein ID: WP_162901697.1
Location: 4660858..4661043 (186 bp)
Type: Others
Protein ID: Protein_4271
Location: 4661183..4661644 (462 bp)
Type: Others
Protein ID: WP_117414055.1
Location: 4661638..4662471 (834 bp)
Type: Others
Protein ID: WP_117414056.1
Location: 4662596..4662985 (390 bp)
Type: Others
Protein ID: WP_117414057.1
Location: 4663079..4663360 (282 bp)
Type: Toxin
Protein ID: WP_117414058.1
Location: 4663370..4663669 (300 bp)
Type: Antitoxin
Protein ID: WP_117414059.1
Location: 4663838..4664188 (351 bp)
Type: Others
Protein ID: WP_117414060.1
Location: 4664185..4665270 (1086 bp)
Type: Others
Protein ID: WP_117414061.1
Location: 4665282..4666163 (882 bp)
Type: Others
Protein ID: WP_117414062.1
Location: 4666214..4666498 (285 bp)
Type: Others
Protein ID: WP_117414063.1
Location: 4666656..4667579 (924 bp)
Type: Others
Protein ID: WP_117414064.1
Location: 4667771..4668028 (258 bp)
Type: Others
Protein ID: WP_162901698.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D1F64_RS212804659615..4660682+1068WP_117414769.1hypothetical protein-
D1F64_RS236504660682..4660846+165WP_162901697.1hypothetical protein-
D1F64_RS212854660858..4661043+186Protein_4271RNA polymerase sigma factor RpoD-
D1F64_RS212904661183..4661644+462WP_117414055.1hypothetical protein-
D1F64_RS212954661638..4662471+834WP_117414056.1DUF930 domain-containing protein-
D1F64_RS213004662596..4662985+390WP_117414057.1DoxX family protein-
D1F64_RS213054663079..4663360+282WP_117414058.1type II toxin-antitoxin system RelE/ParE family toxinToxin
D1F64_RS213104663370..4663669+300WP_117414059.1HigA family addiction module antidote proteinAntitoxin
D1F64_RS213154663838..4664188+351WP_117414060.1metalloregulator ArsR/SmtB family transcription factor-
D1F64_RS213204664185..4665270+1086WP_117414061.1permease-
D1F64_RS213254665282..4666163+882WP_117414062.1transglutaminase-like domain-containing protein-
D1F64_RS213304666214..4666498+285WP_117414063.1SelT/SelW/SelH family protein-
D1F64_RS213354666656..4667579+924WP_117414064.1DMT family transporter-
D1F64_RS213404667771..4668028+258WP_162901698.1DUF1344 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-96)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.58 Da        Isoelectric Point: 11.0696

>T110309 WP_117414058.1 NZ_CP031841:4663079-4663360 [Breoghania sp. L-A4]
MIKSFADKETRRVFERRRSRRLPENIQRRAQIKLAQINAATVLDDLRVPPSNHLESLKGSRAGQHSIRINVQWRICFQWR
DGHACDVEIVDYH

Download         Length: 282 bp

>T110309 NZ_CP031841:4663079-4663360 [Breoghania sp. L-A4]
ATGATCAAGAGTTTCGCGGACAAGGAAACCCGGCGGGTTTTCGAGCGGCGGCGCTCCCGTCGTTTGCCGGAAAATATTCA
GCGGCGGGCGCAGATAAAACTCGCACAGATCAACGCGGCGACTGTTCTCGACGATTTGCGCGTGCCGCCGAGCAACCATC
TGGAAAGCCTCAAGGGCAGCCGCGCCGGGCAACATTCGATCCGCATCAACGTGCAATGGCGGATTTGCTTCCAGTGGCGC
GACGGTCACGCCTGCGACGTCGAAATCGTCGACTATCATTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11219.87 Da        Isoelectric Point: 5.7185

>AT110309 WP_117414059.1 NZ_CP031841:4663370-4663669 [Breoghania sp. L-A4]
MSDDRFAPIHPGEILREEYLPEFGLTAYGLAKALHVPRDRIEALVRERRGITADTALRLGRFFGQTPDFWLNLQTQYDLE
VARLKLGADLEGIAPLRVA

Download         Length: 300 bp

>AT110309 NZ_CP031841:4663370-4663669 [Breoghania sp. L-A4]
ATGAGCGACGATCGATTTGCACCGATCCACCCAGGCGAAATCCTGCGTGAGGAGTATCTTCCGGAATTCGGCTTGACGGC
CTACGGCCTTGCGAAGGCCCTGCACGTTCCGCGCGACCGTATTGAAGCGCTGGTGCGGGAAAGGCGCGGCATCACCGCGG
ACACGGCGCTGCGTCTCGGCCGCTTCTTTGGTCAGACGCCTGACTTCTGGCTCAACCTGCAGACGCAGTACGACCTCGAG
GTCGCGCGGTTGAAGCTTGGCGCGGATCTTGAGGGGATCGCGCCGCTTCGCGTCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References