Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3535372..3535993 Replicon chromosome
Accession NZ_CP031841
Organism Breoghania sp. L-A4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D1F64_RS16160 Protein ID WP_117413263.1
Coordinates 3535712..3535993 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag D1F64_RS16155 Protein ID WP_117413262.1
Coordinates 3535372..3535647 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1F64_RS16130 3530378..3530806 - 429 WP_117413258.1 transcriptional repressor -
D1F64_RS16135 3530803..3531629 - 827 Protein_3240 metal ABC transporter permease -
D1F64_RS16140 3531619..3532497 - 879 WP_117413259.1 metal ABC transporter ATP-binding protein -
D1F64_RS16145 3532717..3533658 + 942 WP_117413260.1 zinc ABC transporter substrate-binding protein ZnuA -
D1F64_RS16150 3533784..3535361 + 1578 WP_117413261.1 adenylate/guanylate cyclase domain-containing protein -
D1F64_RS16155 3535372..3535647 - 276 WP_117413262.1 HigA family addiction module antidote protein Antitoxin
D1F64_RS16160 3535712..3535993 - 282 WP_117413263.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D1F64_RS16165 3536137..3536502 - 366 WP_117413264.1 hypothetical protein -
D1F64_RS16170 3536605..3537048 - 444 WP_117413265.1 SRPBCC family protein -
D1F64_RS16175 3537051..3537455 - 405 WP_117413266.1 DUF1428 domain-containing protein -
D1F64_RS16180 3537486..3537965 - 480 WP_117413267.1 VOC family protein -
D1F64_RS16185 3538024..3538632 - 609 WP_117413268.1 dihydrofolate reductase family protein -
D1F64_RS16190 3538629..3539267 - 639 WP_117413269.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(16-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-61)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10381.04 Da        Isoelectric Point: 9.5019

>T110308 WP_117413263.1 NZ_CP031841:c3535993-3535712 [Breoghania sp. L-A4]
MIRSYKGKMVLAVAVGRAAKGFPTDLVKPAIRKLTMIEYAAALGDLRSPPGNRLEKLSGDRVGQYSIRINDQWRICFVWT
DGGAEEVEIVDYH

Download         Length: 282 bp

>T110308 NZ_CP031841:c3535993-3535712 [Breoghania sp. L-A4]
ATGATCCGGTCTTACAAGGGCAAGATGGTTCTGGCGGTGGCGGTTGGAAGAGCCGCGAAGGGGTTTCCTACCGATCTCGT
AAAACCGGCCATTCGCAAACTGACGATGATCGAGTATGCGGCCGCGCTCGGCGACCTTCGTTCTCCTCCCGGCAACCGGC
TCGAAAAACTGTCGGGCGATCGGGTCGGCCAGTACTCGATCCGCATCAACGACCAATGGCGGATCTGTTTCGTTTGGACA
GACGGCGGCGCCGAAGAGGTCGAAATCGTTGACTATCATTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10013.65 Da        Isoelectric Point: 7.0124

>AT110308 WP_117413262.1 NZ_CP031841:c3535647-3535372 [Breoghania sp. L-A4]
VHPGEILREEYLLPIGMSAGALAKRLGVPRTRIERVATEQTPITPDTALRLAKFFKTTPEFWMNMQTGYDIKIAAAAKAE
EIAAIPTFEAA

Download         Length: 276 bp

>AT110308 NZ_CP031841:c3535647-3535372 [Breoghania sp. L-A4]
GTGCACCCGGGGGAGATTCTGCGCGAGGAGTATCTGCTTCCGATCGGGATGAGCGCCGGCGCTCTGGCAAAACGGCTCGG
CGTGCCCCGCACGCGTATCGAGCGGGTCGCCACGGAACAGACGCCGATCACGCCCGACACCGCGTTGAGGCTTGCGAAAT
TCTTCAAGACGACGCCCGAGTTCTGGATGAACATGCAGACCGGTTACGACATCAAGATCGCGGCCGCCGCCAAAGCCGAG
GAGATCGCCGCTATCCCGACGTTCGAGGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References