Detailed information of TA system TA110302

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1209881..1210460
• Replicon: chromosome
• Accession: NZ_CP031839
• Organism: Staphylococcus aureus strain NX-T55

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: D1O27_RS06550
• Protein ID: WP_001025401.1
• Coordinates: 1209881..1210126 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1210095..1210460 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1O27_RS06495	1205261..1205407	-	147	WP_074370993.1	hypothetical protein	-
D1O27_RS06500	1205443..1205626	-	184	Protein_1180	hypothetical protein	-
D1O27_RS06505	1205722..1206642	-	921	WP_031903415.1	3'-5' exoribonuclease	-
D1O27_RS06510	1206658..1207272	-	615	WP_000801423.1	XRE family transcriptional regulator	-
D1O27_RS06515	1207444..1207671	+	228	WP_001030311.1	hypothetical protein	-
D1O27_RS06520	1207697..1208473	+	777	WP_117346058.1	phage antirepressor	-
D1O27_RS06525	1208489..1208707	+	219	WP_001001383.1	hypothetical protein	-
D1O27_RS06530	1208757..1208900	+	144	WP_000939498.1	hypothetical protein	-
D1O27_RS14930	1208992..1209180	-	189	Protein_1187	uracil-DNA glycosylase	-
D1O27_RS06540	1209250..1209447	+	198	WP_001148860.1	hypothetical protein	-
D1O27_RS06545	1209434..1209814	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
D1O27_RS06550	1209881..1210126	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
D1O27_RS06555	1210095..1210460	-	366	WP_001128433.1	hypothetical protein	Antitoxin
D1O27_RS06560	1210515..1210730	+	216	WP_001097552.1	hypothetical protein	-
D1O27_RS06565	1210757..1211020	+	264	WP_001124196.1	helix-turn-helix domain-containing protein	-
D1O27_RS06570	1211033..1211194	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
D1O27_RS06575	1211289..1211591	+	303	WP_001608484.1	DUF2482 family protein	-
D1O27_RS06580	1211596..1211856	+	261	WP_031584888.1	DUF1108 family protein	-
D1O27_RS06585	1211866..1212087	+	222	WP_000815401.1	DUF2483 family protein	-
D1O27_RS06590	1212080..1212703	+	624	WP_047554413.1	DUF1071 domain-containing protein	-
D1O27_RS06595	1212703..1213128	+	426	WP_117346059.1	single-stranded DNA-binding protein	-
D1O27_RS06600	1213139..1213690	+	552	WP_001004506.1	NUMOD4 motif-containing HNH endonuclease	-
D1O27_RS06605	1213691..1214365	+	675	WP_117346060.1	hypothetical protein	-
D1O27_RS06610	1214358..1215110	+	753	WP_031584871.1	DnaD domain protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T110302 WP_001025401.1 NZ_CP031839:1209881-1210126 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T110302 NZ_CP031839:1209881-1210126 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT110302 NZ_CP031839:c1210460-1210095 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin