Detailed information of TA system TA110289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 264300..264823
• Replicon: chromosome
• Accession: NZ_CP031839
• Organism: Staphylococcus aureus strain NX-T55

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: D1O27_RS01360
• Protein ID: WP_000074043.1
• Coordinates: 264557..264823 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: D1O27_RS01355
• Protein ID: WP_000587618.1
• Coordinates: 264300..264557 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1O27_RS01330	259373..260566	+	1194	WP_000675407.1	MFS transporter	-
D1O27_RS01335	260797..261546	-	750	WP_000072466.1	hypothetical protein	-
D1O27_RS01340	261741..263318	+	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
D1O27_RS01345	263486..263941	-	456	WP_000732076.1	DUF1307 domain-containing protein	-
D1O27_RS01355	264300..264557	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1O27_RS01360	264557..264823	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
D1O27_RS01365	265179..266255	+	1077	WP_001076673.1	M42 family metallopeptidase	-
D1O27_RS01370	266503..267165	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
D1O27_RS01375	267158..267934	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
D1O27_RS01380	268330..269517	+	1188	WP_000026194.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T110289 WP_000074043.1 NZ_CP031839:264557-264823 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T110289 NZ_CP031839:264557-264823 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT110289 WP_000587618.1 NZ_CP031839:264300-264557 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT110289 NZ_CP031839:264300-264557 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2