Detailed information of TA system TA110285

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1842726..1843305
• Replicon: chromosome
• Accession: NZ_CP031838
• Organism: Staphylococcus aureus strain QD-CD9

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: D1G35_RS09680
• Protein ID: WP_001025401.1
• Coordinates: 1843060..1843305 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1842726..1843091 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1G35_RS09620	1838266..1838622	-	357	WP_001132243.1	hypothetical protein	-
D1G35_RS09625	1838622..1839374	-	753	WP_031584871.1	DnaD domain protein	-
D1G35_RS09630	1839367..1840041	-	675	WP_031584874.1	hypothetical protein	-
D1G35_RS09635	1840055..1840483	-	429	WP_031584877.1	single-stranded DNA-binding protein	-
D1G35_RS09640	1840483..1841106	-	624	WP_000139720.1	DUF1071 domain-containing protein	-
D1G35_RS09645	1841099..1841320	-	222	WP_000815401.1	DUF2483 family protein	-
D1G35_RS09650	1841330..1841590	-	261	WP_031584888.1	DUF1108 family protein	-
D1G35_RS09655	1841595..1841897	-	303	WP_001608484.1	DUF2482 family protein	-
D1G35_RS09660	1841992..1842153	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
D1G35_RS09665	1842166..1842429	-	264	WP_001124196.1	helix-turn-helix domain-containing protein	-
D1G35_RS09670	1842456..1842671	-	216	WP_001097552.1	hypothetical protein	-
D1G35_RS09675	1842726..1843091	+	366	WP_001128433.1	hypothetical protein	Antitoxin
D1G35_RS09680	1843060..1843305	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
D1G35_RS09685	1843372..1843752	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
D1G35_RS09690	1843739..1843936	-	198	WP_001148860.1	hypothetical protein	-
D1G35_RS09695	1843952..1844704	-	753	WP_001148605.1	phage antirepressor KilAC domain-containing protein	-
D1G35_RS09700	1844755..1845084	+	330	WP_000128907.1	hypothetical protein	-
D1G35_RS09705	1845073..1845288	-	216	WP_001025404.1	DUF2829 domain-containing protein	-
D1G35_RS09710	1845304..1845567	-	264	WP_000854072.1	helix-turn-helix domain-containing protein	-
D1G35_RS09715	1845564..1845737	-	174	WP_001801500.1	hypothetical protein	-
D1G35_RS09720	1845700..1846413	+	714	WP_001031454.1	XRE family transcriptional regulator	-
D1G35_RS09725	1846429..1847361	+	933	WP_000759682.1	ATP-dependent helicase	-
D1G35_RS09730	1847367..1847708	+	342	WP_000591749.1	hypothetical protein	-
D1G35_RS09735	1847912..1848058	+	147	WP_113342690.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1806716..1850000	43284

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T110285 WP_001025401.1 NZ_CP031838:c1843305-1843060 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T110285 NZ_CP031838:c1843305-1843060 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT110285 NZ_CP031838:1842726-1843091 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin