110275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 387654..388171 Replicon chromosome
Accession NZ_CP031838
Organism Staphylococcus aureus strain QD-CD9

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag D1G35_RS01970 Protein ID WP_000113262.1
Coordinates 387905..388171 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag D1G35_RS01965 Protein ID WP_000584499.1
Coordinates 387654..387905 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1G35_RS01935 383352..384071 + 720 WP_000479576.1 amino acid ABC transporter permease -
D1G35_RS01940 384068..384799 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
D1G35_RS01945 384896..386146 - 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
D1G35_RS01950 386401..386763 + 363 WP_000819843.1 DUF4467 domain-containing protein -
D1G35_RS01955 386782..387381 + 600 WP_000162813.1 DsbA family protein -
D1G35_RS01960 387388..387489 + 102 WP_031774922.1 hypothetical protein -
D1G35_RS01965 387654..387905 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D1G35_RS01970 387905..388171 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
D1G35_RS01975 388467..390017 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
D1G35_RS01980 390203..390670 + 468 WP_000153344.1 SRPBCC domain-containing protein -
D1G35_RS01985 390754..390936 + 183 WP_000230294.1 hypothetical protein -
D1G35_RS01990 391153..391977 + 825 WP_117346096.1 formate/nitrite transporter family protein -
D1G35_RS01995 392210..392746 + 537 WP_031585827.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T110275 WP_000113262.1 NZ_CP031838:387905-388171 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T110275 NZ_CP031838:387905-388171 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT110275 WP_000584499.1 NZ_CP031838:387654-387905 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT110275 NZ_CP031838:387654-387905 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References