Detailed information of TA system TA110273

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 362754..362938
• Replicon: chromosome
• Accession: NZ_CP031838
• Organism: Staphylococcus aureus strain QD-CD9

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: D1G35_RS01810
• Protein ID: WP_000482647.1
• Coordinates: 362754..362861 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	362878..362938 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1G35_RS01785	358126..358599	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
D1G35_RS01790	358722..359933	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
D1G35_RS01795	360115..360774	-	660	WP_000831298.1	membrane protein	-
D1G35_RS01800	360834..361976	-	1143	WP_001176863.1	glycerate kinase	-
D1G35_RS01805	362234..362620	+	387	WP_000779360.1	flippase GtxA	-
D1G35_RS01810	362754..362861	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	362878..362938	-	61	-	-	Antitoxin
D1G35_RS01820	363489..365252	+	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
D1G35_RS01825	365277..367010	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
D1G35_RS01835	367241..367408	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T110273 WP_000482647.1 NZ_CP031838:362754-362861 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T110273 NZ_CP031838:362754-362861 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT110273 NZ_CP031838:c362938-362878 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin