Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 469..970 Replicon plasmid unnamed3
Accession NZ_CP031820
Organism Klebsiella pneumoniae strain INF235-sc-2280127

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2J4ZS98
Locus tag D0898_RS27955 Protein ID WP_019725129.1
Coordinates 695..970 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2J4ZS71
Locus tag D0898_RS27950 Protein ID WP_025987695.1
Coordinates 469..714 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0898_RS29055 71..232 - 162 WP_162870772.1 hypothetical protein -
D0898_RS27950 469..714 + 246 WP_025987695.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D0898_RS27955 695..970 + 276 WP_019725129.1 Txe/YoeB family addiction module toxin Toxin
D0898_RS27960 1218..2123 + 906 WP_019725130.1 replication initiation protein -
D0898_RS27965 2120..2827 + 708 WP_004198042.1 hypothetical protein -
D0898_RS27970 2864..3478 - 615 WP_019725132.1 TIR domain-containing protein -
D0898_RS27975 3880..4281 + 402 WP_019725133.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..6211 6211
- flank IS/Tn - - 5122..6114 992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10902.41 Da        Isoelectric Point: 10.2004

>T110247 WP_019725129.1 NZ_CP031820:695-970 [Klebsiella pneumoniae]
MSKWNIKFTRNGADDLNYWRDTDKKKFERIRQLLLSIEADPLTGIGKPERLRHHKDPALYSRRIDQSHRLVYSIQNGEII
IYAARYHYGDK

Download         Length: 276 bp

>T110247 NZ_CP031820:695-970 [Klebsiella pneumoniae]
TTGTCGAAGTGGAATATTAAGTTCACTAGGAATGGCGCTGATGACCTTAACTACTGGCGTGATACTGACAAAAAGAAGTT
TGAGCGTATCCGGCAACTGTTGCTCAGCATCGAGGCTGATCCGCTGACAGGTATAGGAAAACCCGAACGGCTGCGGCACC
ACAAAGATCCGGCACTCTACTCCCGCAGGATTGATCAGAGCCACCGTCTGGTCTATTCAATCCAGAACGGAGAAATCATC
ATCTACGCAGCCCGTTATCACTATGGTGACAAATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9361.49 Da        Isoelectric Point: 4.4269

>AT110247 WP_025987695.1 NZ_CP031820:469-714 [Klebsiella pneumoniae]
MHAINFTDARKHFAETMKRVTDDAEPVRVMRRDAPDIVMIDAGEYEALIETVYLFSNPANAEHINESMKQAERGEFVEVE
Y

Download         Length: 246 bp

>AT110247 NZ_CP031820:469-714 [Klebsiella pneumoniae]
ATGCATGCAATCAATTTTACTGATGCCCGTAAACATTTTGCCGAGACGATGAAGCGCGTCACTGATGATGCTGAACCGGT
ACGTGTCATGCGCCGTGATGCGCCTGATATTGTTATGATCGATGCGGGAGAGTATGAGGCGCTAATCGAAACGGTCTATC
TGTTCAGCAATCCGGCGAACGCAGAGCATATCAATGAGTCAATGAAACAGGCGGAGCGCGGCGAATTTGTCGAAGTGGAA
TATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZS98

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZS71

References