Detailed information of TA system TA110052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2703115..2703809
• Replicon: chromosome
• Accession: NZ_CP031780
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_342

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: CEQ20_RS12710
• Protein ID: WP_002214787.1
• Coordinates: 2703513..2703809 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: CEQ20_RS12705
• Protein ID: WP_002209924.1
• Coordinates: 2703115..2703513 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ20_RS12675	2698305..2698670	+	366	WP_002209919.1	hypothetical protein	-
CEQ20_RS12680	2698683..2698919	+	237	WP_002214792.1	hypothetical protein	-
CEQ20_RS12685	2698925..2699257	+	333	WP_002214791.1	hypothetical protein	-
CEQ20_RS12690	2699439..2699639	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
CEQ20_RS23060	2699653..2699805	-	153	WP_002209921.1	hypothetical protein	-
CEQ20_RS12695	2699798..2700124	-	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CEQ20_RS12700	2700424..2702715	+	2292	WP_050320982.1	toprim domain-containing protein	-
CEQ20_RS12705	2703115..2703513	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CEQ20_RS12710	2703513..2703809	-	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CEQ20_RS12715	2703973..2704335	-	363	WP_002209925.1	helix-turn-helix domain-containing protein	-
CEQ20_RS12720	2704398..2704658	-	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CEQ20_RS12725	2705256..2705465	+	210	WP_050320983.1	hypothetical protein	-
CEQ20_RS12730	2705521..2706735	-	1215	Protein_2381	tyrosine-type recombinase/integrase	-
CEQ20_RS12740	2707168..2708685	-	1518	WP_002209930.1	lysine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T110052 WP_002214787.1 NZ_CP031780:c2703809-2703513 [Yersinia pseudotuberculosis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T110052 NZ_CP031780:c2703809-2703513 [Yersinia pseudotuberculosis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT110052 WP_002209924.1 NZ_CP031780:c2703513-2703115 [Yersinia pseudotuberculosis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT110052 NZ_CP031780:c2703513-2703115 [Yersinia pseudotuberculosis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1