Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2468384..2468568 Replicon chromosome
Accession NZ_CP031779
Organism Staphylococcus aureus strain CFBR-105

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag D1F65_RS12740 Protein ID WP_000482652.1
Coordinates 2468461..2468568 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2468384..2468444 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1F65_RS12715 2463839..2464006 - 168 Protein_2341 hypothetical protein -
D1F65_RS12725 2464237..2465970 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
D1F65_RS12730 2465995..2467758 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2468384..2468444 + 61 - - Antitoxin
D1F65_RS12740 2468461..2468568 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
D1F65_RS12745 2468702..2469088 - 387 WP_000779360.1 flippase GtxA -
D1F65_RS12750 2469356..2470498 + 1143 WP_001176863.1 glycerate kinase -
D1F65_RS12755 2470558..2471217 + 660 WP_000831298.1 membrane protein -
D1F65_RS12760 2471399..2472610 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
D1F65_RS12765 2472733..2473206 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T110036 WP_000482652.1 NZ_CP031779:c2468568-2468461 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T110036 NZ_CP031779:c2468568-2468461 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT110036 NZ_CP031779:2468384-2468444 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References