Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2181591..2181853 Replicon chromosome
Accession NZ_CP031779
Organism Staphylococcus aureus strain CFBR-105

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag D1F65_RS11170 Protein ID WP_001802298.1
Coordinates 2181749..2181853 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2181591..2181754 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1F65_RS11150 2177843..2178508 - 666 WP_001024095.1 SDR family oxidoreductase -
D1F65_RS11155 2178660..2178980 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
D1F65_RS11160 2178982..2179959 + 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
D1F65_RS11165 2180225..2181316 + 1092 WP_000495669.1 hypothetical protein -
- 2181591..2181754 + 164 - - Antitoxin
D1F65_RS11170 2181749..2181853 - 105 WP_001802298.1 hypothetical protein Toxin
D1F65_RS11180 2182533..2182691 + 159 WP_001792784.1 hypothetical protein -
D1F65_RS11190 2183349..2184206 - 858 WP_000370923.1 Cof-type HAD-IIB family hydrolase -
D1F65_RS11195 2184274..2185056 - 783 WP_000908182.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T110035 WP_001802298.1 NZ_CP031779:c2181853-2181749 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T110035 NZ_CP031779:c2181853-2181749 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT110035 NZ_CP031779:2181591-2181754 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References