Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 167423..167939 Replicon plasmid p.A
Accession NZ_CP031752
Organism Cereibacter sphaeroides strain EBL0706

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag D0Z66_RS20235 Protein ID WP_011910969.1
Coordinates 167673..167939 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag D0Z66_RS20230 Protein ID WP_011910970.1
Coordinates 167423..167692 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z66_RS20210 162914..164251 + 1338 WP_011910974.1 ferric reductase-like transmembrane domain-containing protein -
D0Z66_RS20215 164345..164536 + 192 WP_101339530.1 Hin recombinase -
D0Z66_RS20220 164629..165834 - 1206 WP_011910972.1 sodium/glutamate symporter -
D0Z66_RS20225 166232..166819 + 588 Protein_146 Tn3 family transposase -
D0Z66_RS20230 167423..167692 + 270 WP_011910970.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D0Z66_RS20235 167673..167939 + 267 WP_011910969.1 Txe/YoeB family addiction module toxin Toxin
D0Z66_RS20240 168197..168421 + 225 WP_108222325.1 transcriptional regulator/antitoxin MazE -
D0Z66_RS20245 168418..168822 + 405 WP_011910966.1 type II toxin-antitoxin system death-on-curing family toxin -
D0Z66_RS20250 168862..169071 - 210 Protein_151 excisionase family DNA-binding protein -
D0Z66_RS20255 169197..169376 + 180 WP_101339531.1 hypothetical protein -
D0Z66_RS22250 169495..169659 + 165 WP_180325088.1 hypothetical protein -
D0Z66_RS20260 169681..170604 - 924 WP_117345223.1 DMT family transporter -
D0Z66_RS20265 170724..171527 - 804 WP_117345224.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..298364 298364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10329.63 Da        Isoelectric Point: 9.5467

>T109991 WP_011910969.1 NZ_CP031752:167673-167939 [Cereibacter sphaeroides]
MKLIFSDRAWDDYHHWHQTDATIFERLNGLIKEASRQPFRGTGKPEPLKGDLSGWWSRRLTGEHRLVYRVSGSGVTQALE
IAQCRYHY

Download         Length: 267 bp

>T109991 NZ_CP031752:167673-167939 [Cereibacter sphaeroides]
ATGAAACTGATATTCTCTGACCGGGCCTGGGATGATTACCACCATTGGCACCAGACAGACGCCACGATCTTCGAGCGGCT
GAACGGACTGATCAAGGAGGCCTCACGCCAGCCGTTCCGAGGCACCGGGAAACCGGAACCCTTGAAGGGGGACCTGTCGG
GTTGGTGGTCGCGCCGGCTGACCGGAGAGCACCGCCTCGTGTATCGGGTTTCCGGGAGCGGTGTGACGCAAGCGCTGGAG
ATTGCCCAGTGCCGCTATCACTACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9841.06 Da        Isoelectric Point: 4.5069

>AT109991 WP_011910970.1 NZ_CP031752:167423-167692 [Cereibacter sphaeroides]
MNILTYTDARKHLKSVMDSAIHDKEETVITRAGQEAVVVVGKEEWDAIQATLHLLSSPVNAARLRESIAQLNAGQGTERD
LIEDETDIL

Download         Length: 270 bp

>AT109991 NZ_CP031752:167423-167692 [Cereibacter sphaeroides]
ATGAACATCCTCACCTATACGGATGCTCGAAAGCATCTGAAATCCGTCATGGATTCCGCTATCCATGACAAAGAGGAAAC
CGTGATTACCCGCGCGGGCCAGGAAGCTGTCGTCGTCGTCGGGAAAGAAGAATGGGATGCGATCCAGGCAACGCTCCATC
TTCTGTCGTCACCGGTCAACGCCGCCCGACTGCGGGAATCCATTGCTCAGCTGAACGCCGGGCAAGGAACGGAGCGAGAC
CTGATCGAAGATGAAACTGATATTCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References