Detailed information of TA system TA109990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 164036..164574
• Replicon: chromosome
• Accession: NZ_CP031746
• Organism: Auritidibacter sp. NML130574

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: DCC27_RS12275
• Protein ID: WP_199445857.1
• Coordinates: 164036..164263 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: DCC27_RS00860
• Protein ID: WP_110100392.1
• Coordinates: 164269..164574 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCC27_RS00825	160099..161184	+	1086	WP_110100193.1	redox-regulated ATPase YchF	-
DCC27_RS00830	161332..161565	+	234	WP_110100006.1	Arc family DNA-binding protein	-
DCC27_RS00835	161562..161987	+	426	WP_110100194.1	type II toxin-antitoxin system VapC family toxin	-
DCC27_RS00840	162000..162536	+	537	WP_158524689.1	GNAT family N-acetyltransferase	-
DCC27_RS00845	162682..162876	-	195	WP_146206388.1	hypothetical protein	-
DCC27_RS00850	163080..163805	+	726	WP_110100197.1	hypothetical protein	-
DCC27_RS12275	164036..164263	+	228	WP_199445857.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DCC27_RS00860	164269..164574	+	306	WP_110100392.1	helix-turn-helix domain-containing protein	Antitoxin
DCC27_RS00865	164725..164958	+	234	WP_110100198.1	hypothetical protein	-
DCC27_RS00870	164943..165317	+	375	WP_146206389.1	hypothetical protein	-
DCC27_RS00875	165583..166347	+	765	WP_110100200.1	sulfite exporter TauE/SafE family protein	-
DCC27_RS00885	167423..168145	+	723	WP_110100393.1	sulfite exporter TauE/SafE family protein	-
DCC27_RS12065	168184..168660	+	477	WP_148707488.1	hypothetical protein	-
DCC27_RS00895	168902..169288	+	387	WP_110100203.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (11-65)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-88)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8777.09 Da
• Isoelectric Point: 9.8609

>T109990 WP_199445857.1 NZ_CP031746:164036-164263 [Auritidibacter sp. NML130574]
IVDSVAGSRHKNMKELRPGSSGRSELRVLFAFDPERVAIMLIAEDKIGDWKRWYKKHISLADDLFDEHLARLRRE

Nucleotide

• Length: 228 bp

>T109990 NZ_CP031746:164036-164263 [Auritidibacter sp. NML130574]
ATCGTCGACAGTGTAGCCGGGTCCCGGCATAAGAATATGAAAGAGCTCAGGCCCGGCTCGTCTGGCCGGTCCGAGTTGCG
CGTTCTGTTCGCGTTCGATCCAGAGCGAGTGGCGATCATGCTGATCGCCGAAGATAAGATCGGCGATTGGAAACGCTGGT
ATAAGAAGCACATTTCGTTGGCCGACGACCTCTTCGACGAGCATCTGGCCCGACTGAGAAGAGAGTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11378.08 Da
• Isoelectric Point: 9.9101

>AT109990 WP_110100392.1 NZ_CP031746:164269-164574 [Auritidibacter sp. NML130574]
MPKNLKDFVAEHPVDRGRVEAHKKRMLAEVRAYRLRELREQAGLTQAQLAERIGVGQRQVSKIEQGDLDSAKVGTIRSYL
EAVGGELSLEYVMGDQRMKVA

Nucleotide

• Length: 306 bp

>AT109990 NZ_CP031746:164269-164574 [Auritidibacter sp. NML130574]
ATGCCAAAGAACCTGAAGGATTTCGTCGCCGAGCATCCTGTTGACCGGGGACGGGTTGAGGCGCACAAGAAGCGGATGCT
TGCTGAGGTTCGCGCCTACCGTCTGCGAGAGCTACGGGAGCAGGCCGGACTGACGCAAGCGCAGCTGGCAGAGCGCATTG
GCGTCGGGCAGCGGCAGGTTTCGAAGATCGAGCAAGGCGACCTCGACAGCGCGAAGGTTGGCACCATCCGCAGTTACCTT
GAGGCCGTCGGTGGCGAACTCTCCCTTGAGTACGTGATGGGAGACCAGCGAATGAAGGTCGCCTAA