Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4509604..4510181 Replicon chromosome
Accession NZ_CP031728
Organism Cellvibrio sp. KY-GH-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D0C16_RS19005 Protein ID WP_151033814.1
Coordinates 4509604..4509882 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D0C16_RS19010 Protein ID WP_151033815.1
Coordinates 4509882..4510181 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0C16_RS18985 4505238..4506824 - 1587 WP_151033810.1 regulator -
D0C16_RS18990 4506937..4507629 - 693 WP_151033811.1 cysteine hydrolase -
D0C16_RS18995 4507740..4508459 - 720 WP_191968552.1 DUF5020 domain-containing protein -
D0C16_RS19000 4508871..4509545 + 675 WP_151033813.1 GntR family transcriptional regulator -
D0C16_RS19005 4509604..4509882 + 279 WP_151033814.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0C16_RS19010 4509882..4510181 + 300 WP_151033815.1 HigA family addiction module antidote protein Antitoxin
D0C16_RS19015 4510181..4510645 + 465 WP_151033816.1 DUF2721 domain-containing protein -
D0C16_RS19020 4510936..4511406 + 471 WP_151033817.1 hypothetical protein -
D0C16_RS19025 4511460..4512479 - 1020 WP_151033818.1 cytochrome d ubiquinol oxidase subunit II -
D0C16_RS19030 4512490..4513860 - 1371 WP_151033819.1 cytochrome ubiquinol oxidase subunit I -
D0C16_RS19035 4514033..4514596 - 564 WP_151033820.1 GbsR/MarR family transcriptional regulator -
D0C16_RS24085 4514683..4514820 + 138 WP_191968553.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10565.16 Da        Isoelectric Point: 8.9983

>T109984 WP_151033814.1 NZ_CP031728:4509604-4509882 [Cellvibrio sp. KY-GH-1]
MIISFKHKGLERFYRSGSLSGIQAAHSRRLQLILTNLDCAAEPSDMNLPGLRLHELKGDMKGVWSVFVNGNWRVTFRFVG
INVELVNYEDYH

Download         Length: 279 bp

>T109984 NZ_CP031728:4509604-4509882 [Cellvibrio sp. KY-GH-1]
ATGATTATTTCATTCAAGCACAAAGGACTTGAGCGTTTTTACCGGTCAGGAAGTCTCTCCGGCATTCAGGCGGCGCACTC
GCGCCGATTACAATTGATTCTTACCAATCTTGACTGCGCAGCCGAGCCTTCGGACATGAATTTGCCTGGGTTACGCTTGC
ATGAGCTCAAAGGTGATATGAAAGGGGTCTGGTCGGTGTTTGTGAATGGAAATTGGCGAGTGACCTTTCGGTTTGTCGGT
ATCAACGTTGAATTGGTTAATTATGAGGATTATCACTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11305.12 Da        Isoelectric Point: 7.3167

>AT109984 WP_151033815.1 NZ_CP031728:4509882-4510181 [Cellvibrio sp. KY-GH-1]
MAMHNPAHPGEILKELMLDPLGLTLTQVAENLDISRKTLSKVINGRGAITPEMAVRLEMAFAEPSADHWLKLQNAYDLWW
ARQYKKEYNVRPFDLKVAS

Download         Length: 300 bp

>AT109984 NZ_CP031728:4509882-4510181 [Cellvibrio sp. KY-GH-1]
ATGGCTATGCATAATCCGGCCCATCCCGGTGAAATTCTGAAAGAGTTAATGCTTGATCCATTGGGATTGACATTAACCCA
GGTGGCAGAAAATTTGGATATCAGCCGCAAAACCCTTTCCAAAGTAATTAATGGCCGCGGTGCCATTACCCCGGAAATGG
CTGTGCGCTTGGAAATGGCGTTTGCCGAGCCCTCTGCCGATCATTGGTTAAAATTGCAGAATGCTTACGACTTATGGTGG
GCGCGACAGTATAAAAAGGAATATAACGTTCGCCCATTTGACTTGAAGGTGGCCAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References