Detailed information of TA system TA109886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4794326..4794915
• Replicon: chromosome
• Accession: NZ_CP031698
• Organism: Xanthomonas oryzae pv. oryzae strain PXO142

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: DZA55_RS23835
• Protein ID: WP_012443754.1
• Coordinates: 4794634..4794915 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DZA55_RS23830
• Protein ID: WP_011260746.1
• Coordinates: 4794326..4794616 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZA55_RS23790 (DZA55_23745)	4789480..4790088	-	609	WP_011409746.1	DUF4123 domain-containing protein	-
DZA55_RS23795 (DZA55_23750)	4790091..4790513	-	423	WP_042465811.1	PAAR domain-containing protein	-
DZA55_RS23800 (DZA55_23755)	4790641..4790967	-	327	WP_228329596.1	hypothetical protein	-
DZA55_RS23810 (DZA55_23765)	4791222..4791554	+	333	WP_011260743.1	hypothetical protein	-
DZA55_RS25625	4791714..4791901	+	188	Protein_4293	hypothetical protein	-
DZA55_RS23820 (DZA55_23775)	4792004..4793397	-	1394	Protein_4294	type III secretion system effector XopQ	-
DZA55_RS23830 (DZA55_23785)	4794326..4794616	-	291	WP_011260746.1	HigA family addiction module antitoxin	Antitoxin
DZA55_RS23835 (DZA55_23790)	4794634..4794915	-	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZA55_RS23840 (DZA55_23795)	4795010..4797262	-	2253	WP_069960050.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.83 Da
• Isoelectric Point: 10.5318

>T109886 WP_012443754.1 NZ_CP031698:c4794915-4794634 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T109886 NZ_CP031698:c4794915-4794634 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT109886 WP_011260746.1 NZ_CP031698:c4794616-4794326 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT109886 NZ_CP031698:c4794616-4794326 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5