Detailed information of TA system TA109878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 347402..347991
• Replicon: chromosome
• Accession: NZ_CP031697
• Organism: Xanthomonas oryzae pv. oryzae strain ICMP3125

Toxin (Protein)

• Gene name: graT
• Uniprot ID: G7TIR7
• Locus tag: DZA53_RS01650
• Protein ID: WP_012443754.1
• Coordinates: 347402..347683 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DZA53_RS01655
• Protein ID: WP_011260746.1
• Coordinates: 347701..347991 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DZA53_RS01645	345055..347307	+	2253	WP_027703653.1	exodeoxyribonuclease V subunit alpha	-
DZA53_RS01650	347402..347683	+	282	WP_012443754.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DZA53_RS01655	347701..347991	+	291	WP_011260746.1	HigA family addiction module antidote protein	Antitoxin
DZA53_RS01665	348920..350314	+	1395	WP_027703652.1	nucleoside hydrolase	-
DZA53_RS01675	350764..351096	-	333	WP_011260743.1	hypothetical protein	-
DZA53_RS01685	351432..351656	+	225	WP_044751358.1	hypothetical protein	-
DZA53_RS01690	351794..352228	+	435	WP_011260742.1	PAAR domain-containing protein	-
DZA53_RS01695	352231..352707	+	477	WP_011260741.1	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.83 Da
• Isoelectric Point: 10.5318

>T109878 WP_012443754.1 NZ_CP031697:347402-347683 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Nucleotide

• Length: 282 bp

>T109878 NZ_CP031697:347402-347683 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCGCATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10420.07 Da
• Isoelectric Point: 7.2040

>AT109878 WP_011260746.1 NZ_CP031697:347701-347991 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT109878 NZ_CP031697:347701-347991 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0K0GFW5