109857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 361879..363227 Replicon chromosome
Accession NZ_CP031692
Organism Haemophilus influenzae strain P595-8370

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag CH556_RS01830 Protein ID WP_116945566.1
Coordinates 362196..363227 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag CH556_RS01825 Protein ID WP_116945567.1
Coordinates 361879..362199 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH556_RS01785 357302..357580 + 279 WP_005665661.1 cell division protein FtsB -
CH556_RS01790 357580..358257 + 678 WP_005655267.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
CH556_RS01795 358254..358730 + 477 WP_116945569.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
CH556_RS01800 359037..359471 - 435 WP_014551116.1 D-tyrosyl-tRNA(Tyr) deacylase -
CH556_RS01805 359468..359908 - 441 WP_005687918.1 FMN-binding protein MioC -
CH556_RS01810 360002..360220 - 219 WP_005650820.1 cell division protein ZapB -
CH556_RS01815 360382..361383 + 1002 WP_116945568.1 class II fructose-bisphosphatase -
CH556_RS01820 361583..361891 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
CH556_RS01825 361879..362199 + 321 WP_116945567.1 type II toxin-antitoxin system HipA family toxin Antitoxin
CH556_RS01830 362196..363227 + 1032 WP_116945566.1 type II toxin-antitoxin system HipA family toxin Toxin
CH556_RS01835 363311..364969 - 1659 WP_116945565.1 thiol reductant ABC exporter subunit CydC -
CH556_RS01840 364962..366707 - 1746 WP_116945564.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39906.48 Da        Isoelectric Point: 6.5671

>T109857 WP_116945566.1 NZ_CP031692:362196-363227 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDDHFDSVDQQ
GHYILKPSPEEYPFLAENEHATMRIMKELEFDVPENGLVPFAGEQNHKEFAFVIKRFDRDEQQTAIHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYAEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T109857 NZ_CP031692:362196-363227 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGTTCATTCTGGCTACAGCACAAAAGGTTTACATTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGGATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGATCACTTTGACAGCGTAGATCAACAG
GGACATTACATTTTAAAGCCTTCGCCCGAAGAGTATCCTTTTTTAGCTGAGAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGAATTTGACGTGCCAGAAAATGGTTTAGTTCCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAACAGCGATTCATCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTGAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACTGAAAA
TCATTTAGCTCAACAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTATCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCACGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGCTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATACCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGTGTACTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12379.04 Da        Isoelectric Point: 5.9670

>AT109857 WP_116945567.1 NZ_CP031692:361879-362199 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLAPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT109857 NZ_CP031692:361879-362199 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCCTATTTTGCATCGCTTGCCCCCGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References