Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 670142..670811 Replicon chromosome
Accession NZ_CP031690
Organism Haemophilus influenzae strain P617-9224

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag CH578_RS03470 Protein ID WP_015701504.1
Coordinates 670142..670525 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag CH578_RS03475 Protein ID WP_005651224.1
Coordinates 670509..670811 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH578_RS03435 666902..667225 + 324 WP_015701510.1 DUF2190 family protein -
CH578_RS03440 667206..667517 + 312 WP_015701509.1 hypothetical protein -
CH578_RS03445 667520..668050 + 531 WP_015701508.1 phage tail protein -
CH578_RS03450 668059..668469 + 411 WP_038440699.1 phage tail protein -
CH578_RS03455 668472..669122 + 651 WP_105880463.1 hypothetical protein -
CH578_RS03460 669397..669804 + 408 WP_038440705.1 hypothetical protein -
CH578_RS03465 669849..670073 + 225 WP_038440708.1 DUF4035 domain-containing protein -
CH578_RS03470 670142..670525 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH578_RS03475 670509..670811 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
CH578_RS03480 670827..671063 + 237 WP_101494098.1 hypothetical protein -
CH578_RS03485 671115..674474 + 3360 WP_048950250.1 phage tail tape measure protein -
CH578_RS03490 674483..674815 + 333 WP_048950249.1 phage tail protein -
CH578_RS09205 674907..675065 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 633846..684675 50829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T109845 WP_015701504.1 NZ_CP031690:670142-670525 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T109845 NZ_CP031690:670142-670525 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT109845 WP_005651224.1 NZ_CP031690:670509-670811 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT109845 NZ_CP031690:670509-670811 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References