Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 662759..663428 Replicon chromosome
Accession NZ_CP031688
Organism Haemophilus influenzae strain P636-8296

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag CH597_RS03400 Protein ID WP_015701504.1
Coordinates 662759..663142 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag CH597_RS03405 Protein ID WP_005651224.1
Coordinates 663126..663428 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH597_RS03365 659519..659842 + 324 WP_048950251.1 DUF2190 family protein -
CH597_RS03370 659823..660134 + 312 WP_015701509.1 hypothetical protein -
CH597_RS03375 660137..660667 + 531 WP_042594859.1 phage tail protein -
CH597_RS03380 660676..661086 + 411 WP_005651206.1 phage tail protein -
CH597_RS03385 661089..661739 + 651 WP_070828282.1 hypothetical protein -
CH597_RS03390 662014..662421 + 408 WP_038440705.1 hypothetical protein -
CH597_RS03395 662466..662690 + 225 WP_038440708.1 DUF4035 domain-containing protein -
CH597_RS03400 662759..663142 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH597_RS03405 663126..663428 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
CH597_RS03410 663444..663680 + 237 WP_101494098.1 hypothetical protein -
CH597_RS03415 663732..667091 + 3360 WP_048950250.1 phage tail tape measure protein -
CH597_RS03420 667100..667432 + 333 WP_048950249.1 phage tail protein -
CH597_RS09120 667524..667682 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 634009..677292 43283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T109832 WP_015701504.1 NZ_CP031688:662759-663142 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T109832 NZ_CP031688:662759-663142 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT109832 WP_005651224.1 NZ_CP031688:663126-663428 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT109832 NZ_CP031688:663126-663428 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References