Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA-HipA |
Location | 361859..363207 | Replicon | chromosome |
Accession | NZ_CP031685 | ||
Organism | Haemophilus influenzae strain P650-8603 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | - |
Locus tag | CH611_RS01830 | Protein ID | WP_116945566.1 |
Coordinates | 362176..363207 (+) | Length | 344 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | - |
Locus tag | CH611_RS01825 | Protein ID | WP_116945567.1 |
Coordinates | 361859..362179 (+) | Length | 107 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CH611_RS01785 | 357282..357560 | + | 279 | WP_005665661.1 | cell division protein FtsB | - |
CH611_RS01790 | 357560..358237 | + | 678 | WP_005655267.1 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | - |
CH611_RS01795 | 358234..358710 | + | 477 | WP_116945569.1 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | - |
CH611_RS01800 | 359017..359451 | - | 435 | WP_014551116.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
CH611_RS01805 | 359448..359888 | - | 441 | WP_005687918.1 | FMN-binding protein MioC | - |
CH611_RS01810 | 359982..360200 | - | 219 | WP_005650820.1 | cell division protein ZapB | - |
CH611_RS01815 | 360362..361363 | + | 1002 | WP_116945568.1 | class II fructose-bisphosphatase | - |
CH611_RS01820 | 361563..361871 | + | 309 | WP_005661200.1 | helix-turn-helix domain-containing protein | - |
CH611_RS01825 | 361859..362179 | + | 321 | WP_116945567.1 | type II toxin-antitoxin system HipA family toxin | Antitoxin |
CH611_RS01830 | 362176..363207 | + | 1032 | WP_116945566.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
CH611_RS01835 | 363291..364949 | - | 1659 | WP_116945565.1 | thiol reductant ABC exporter subunit CydC | - |
CH611_RS01840 | 364942..366687 | - | 1746 | WP_116945564.1 | ABC transporter ATP-binding protein/permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 344 a.a. Molecular weight: 39906.48 Da Isoelectric Point: 6.5671
>T109813 WP_116945566.1 NZ_CP031685:362176-363207 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDDHFDSVDQQ
GHYILKPSPEEYPFLAENEHATMRIMKELEFDVPENGLVPFAGEQNHKEFAFVIKRFDRDEQQTAIHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYAEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDDHFDSVDQQ
GHYILKPSPEEYPFLAENEHATMRIMKELEFDVPENGLVPFAGEQNHKEFAFVIKRFDRDEQQTAIHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYAEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL
Download Length: 1032 bp
>T109813 NZ_CP031685:362176-363207 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGTTCATTCTGGCTACAGCACAAAAGGTTTACATTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGGATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGATCACTTTGACAGCGTAGATCAACAG
GGACATTACATTTTAAAGCCTTCGCCCGAAGAGTATCCTTTTTTAGCTGAGAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGAATTTGACGTGCCAGAAAATGGTTTAGTTCCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAACAGCGATTCATCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTGAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACTGAAAA
TCATTTAGCTCAACAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTATCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCACGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGCTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATACCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGTGTACTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACGTATTAAATGAACCTGAACTATAA
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGTTCATTCTGGCTACAGCACAAAAGGTTTACATTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGGATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGATCACTTTGACAGCGTAGATCAACAG
GGACATTACATTTTAAAGCCTTCGCCCGAAGAGTATCCTTTTTTAGCTGAGAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGAATTTGACGTGCCAGAAAATGGTTTAGTTCCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAACAGCGATTCATCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTGAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACTGAAAA
TCATTTAGCTCAACAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTATCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCACGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGCTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATACCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGTGTACTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACGTATTAAATGAACCTGAACTATAA
Antitoxin
Download Length: 107 a.a. Molecular weight: 12379.04 Da Isoelectric Point: 5.9670
>AT109813 WP_116945567.1 NZ_CP031685:361859-362179 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLAPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLAPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ
Download Length: 321 bp
>AT109813 NZ_CP031685:361859-362179 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCCTATTTTGCATCGCTTGCCCCCGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCCTATTTTGCATCGCTTGCCCCCGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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