109804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 359304..360652 Replicon chromosome
Accession NZ_CP031684
Organism Haemophilus influenzae strain P652-8881

Toxin (Protein)


Gene name HipT Uniprot ID A0A5C6GXP8
Locus tag CH613_RS01835 Protein ID WP_012054635.1
Coordinates 359621..360652 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2R3FM14
Locus tag CH613_RS01830 Protein ID WP_005687922.1
Coordinates 359304..359624 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH613_RS01790 354732..355010 + 279 WP_005665661.1 cell division protein FtsB -
CH613_RS01795 355010..355687 + 678 WP_012054634.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
CH613_RS01800 355684..356160 + 477 WP_005687916.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
CH613_RS01805 356462..356896 - 435 WP_005687917.1 D-tyrosyl-tRNA(Tyr) deacylase -
CH613_RS01810 356893..357333 - 441 WP_005687918.1 FMN-binding protein MioC -
CH613_RS01815 357427..357645 - 219 WP_005650820.1 cell division protein ZapB -
CH613_RS01820 357807..358808 + 1002 WP_005687920.1 class II fructose-bisphosphatase -
CH613_RS01825 359008..359316 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
CH613_RS01830 359304..359624 + 321 WP_005687922.1 type II toxin-antitoxin system HipA family toxin Antitoxin
CH613_RS01835 359621..360652 + 1032 WP_012054635.1 type II toxin-antitoxin system HipA family toxin Toxin
CH613_RS01840 360736..362394 - 1659 WP_012054636.1 thiol reductant ABC exporter subunit CydC -
CH613_RS01845 362387..364132 - 1746 WP_012054637.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39830.34 Da        Isoelectric Point: 6.5052

>T109804 WP_012054635.1 NZ_CP031684:359621-360652 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSDYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T109804 NZ_CP031684:359621-360652 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGACTACAGCACAAAAGGTTTACATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGGGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12407.09 Da        Isoelectric Point: 5.9670

>AT109804 WP_005687922.1 NZ_CP031684:359304-359624 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT109804 NZ_CP031684:359304-359624 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C6GXP8

Antitoxin

Source ID Structure
AlphaFold DB A0A2R3FM14

References