Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1301510..1302149 Replicon chromosome
Accession NZ_CP031683
Organism Haemophilus influenzae strain P662-7189

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CH621_RS06550 Protein ID WP_105872356.1
Coordinates 1301510..1301815 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CH621_RS06555 Protein ID WP_105872355.1
Coordinates 1301826..1302149 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH621_RS06530 1296939..1298978 - 2040 WP_038441065.1 excinuclease ABC subunit B -
CH621_RS06540 1299593..1300561 - 969 WP_050838443.1 zinc transporter permease subunit ZevB -
CH621_RS06545 1300564..1301184 - 621 WP_105872357.1 zinc transporter binding subunit ZevA -
CH621_RS06550 1301510..1301815 + 306 WP_105872356.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH621_RS06555 1301826..1302149 + 324 WP_105872355.1 HigA family addiction module antidote protein Antitoxin
CH621_RS06560 1302312..1303982 + 1671 WP_050838440.1 energy-dependent translational throttle protein EttA -
CH621_RS06565 1304044..1304385 + 342 WP_005652996.1 SirB2 family protein -
CH621_RS06570 1304390..1306360 + 1971 WP_011961904.1 tRNA(Met) cytidine acetyltransferase TmcA -
CH621_RS09610 1306357..1306530 + 174 WP_011272700.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12137.77 Da        Isoelectric Point: 7.3931

>T109799 WP_105872356.1 NZ_CP031683:1301510-1301815 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDAHSKIPSNLSKVLARKLDMISAAEDINDLRSPPANHLELLEPKENKIYSIRVNKQYLL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T109799 NZ_CP031683:1301510-1301815 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATGCTCATAGTAAGAT
TCCTTCTAATTTATCTAAAGTATTGGCAAGAAAATTGGATATGATAAGTGCTGCAGAAGACATCAATGATTTACGTTCTC
CTCCAGCTAATCACTTAGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTAAATAAACAATATCTCCTA
ATTTTTAAATATGAGAATAATGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12258.08 Da        Isoelectric Point: 7.4049

>AT109799 WP_105872355.1 NZ_CP031683:1301826-1302149 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKINDLAQILDVHRNTASNIANNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHGTSAFAM

Download         Length: 324 bp

>AT109799 NZ_CP031683:1301826-1302149 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGCGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAATGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGCTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATTTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGCCTTGCGAATGTTAAGCCCGCTCTACATCGGCATGGCACTTCTGCATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References