Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 685061..685730 Replicon chromosome
Accession NZ_CP031683
Organism Haemophilus influenzae strain P662-7189

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag CH621_RS03540 Protein ID WP_015701504.1
Coordinates 685061..685444 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag CH621_RS03545 Protein ID WP_005651224.1
Coordinates 685428..685730 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH621_RS03505 681821..682144 + 324 WP_059358265.1 DUF2190 family protein -
CH621_RS03510 682125..682436 + 312 WP_015701509.1 hypothetical protein -
CH621_RS03515 682439..682969 + 531 WP_015701508.1 phage tail protein -
CH621_RS03520 682978..683388 + 411 WP_038440699.1 phage tail protein -
CH621_RS03525 683391..684041 + 651 WP_038440702.1 hypothetical protein -
CH621_RS03530 684316..684723 + 408 WP_038440705.1 hypothetical protein -
CH621_RS03535 684768..684992 + 225 WP_038440708.1 DUF4035 domain-containing protein -
CH621_RS03540 685061..685444 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH621_RS03545 685428..685730 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
CH621_RS03550 685746..685982 + 237 WP_101494098.1 hypothetical protein -
CH621_RS03555 686034..689426 + 3393 WP_105887139.1 tape measure protein -
CH621_RS03560 689435..689767 + 333 WP_038440713.1 phage tail protein -
CH621_RS09590 689859..690017 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 652221..703528 51307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T109797 WP_015701504.1 NZ_CP031683:685061-685444 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T109797 NZ_CP031683:685061-685444 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTGCAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT109797 WP_005651224.1 NZ_CP031683:685428-685730 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT109797 NZ_CP031683:685428-685730 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References