Detailed information of TA system TA109793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1327613..1328252
• Replicon: chromosome
• Accession: NZ_CP031682
• Organism: Haemophilus influenzae strain P665-7858

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q4QJX7
• Locus tag: CH624_RS06815
• Protein ID: WP_005650215.1
• Coordinates: 1327613..1327918 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CH624_RS06820
• Protein ID: WP_005692314.1
• Coordinates: 1327929..1328252 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH624_RS06795	1323044..1325083	-	2040	WP_042611248.1	excinuclease ABC subunit B	-
CH624_RS06805	1325697..1326665	-	969	WP_005650211.1	zinc transporter permease subunit ZevB	-
CH624_RS06810	1326668..1327288	-	621	WP_005650213.1	zinc transporter binding subunit ZevA	-
CH624_RS06815	1327613..1327918	+	306	WP_005650215.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CH624_RS06820	1327929..1328252	+	324	WP_005692314.1	HigA family addiction module antidote protein	Antitoxin
CH624_RS06825	1328415..1330085	+	1671	WP_042611251.1	energy-dependent translational throttle protein EttA	-
CH624_RS06830	1330147..1330488	+	342	WP_005652996.1	SirB2 family protein	-
CH624_RS06835	1330493..1332463	+	1971	WP_042611252.1	tRNA(Met) cytidine acetyltransferase TmcA	-
CH624_RS09790	1332460..1332633	+	174	WP_005657572.1	DUF5363 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12301.93 Da
• Isoelectric Point: 9.0853

>T109793 WP_005650215.1 NZ_CP031682:1327613-1327918 [Haemophilus influenzae]
MFNLKREHFRDDYLYRFYQYGDTHSKIPSNLYKVLARKLDMISASENINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Nucleotide

• Length: 306 bp

>T109793 NZ_CP031682:1327613-1327918 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12375.23 Da
• Isoelectric Point: 6.8804

>AT109793 WP_005692314.1 NZ_CP031682:1327929-1328252 [Haemophilus influenzae]
MMTRKPTSVGEILQEEFLEPLSLKISDLAQILDVHRNTVSNIVNNSSRITLEMAVKLAKVFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHDTSTFAM

Nucleotide

• Length: 324 bp

>AT109793 NZ_CP031682:1327929-1328252 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGTAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Structures

Toxin

• AlphaFold DB: A0A806EC70