Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 678915..679584 Replicon chromosome
Accession NZ_CP031679
Organism Haemophilus influenzae strain P676-2514

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag CH635_RS03530 Protein ID WP_015701504.1
Coordinates 678915..679298 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag CH635_RS03535 Protein ID WP_005651224.1
Coordinates 679282..679584 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH635_RS03495 675672..675995 + 324 WP_084999863.1 DUF2190 family protein -
CH635_RS03500 675976..676287 + 312 WP_015701509.1 hypothetical protein -
CH635_RS03505 676290..676820 + 531 WP_015701508.1 phage tail protein -
CH635_RS03510 676829..677239 + 411 WP_038440699.1 phage tail protein -
CH635_RS03515 677242..677892 + 651 WP_050846007.1 hypothetical protein -
CH635_RS03520 678167..678574 + 408 WP_038440705.1 hypothetical protein -
CH635_RS03525 678619..678846 + 228 WP_058222178.1 DUF4035 domain-containing protein -
CH635_RS03530 678915..679298 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CH635_RS03535 679282..679584 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
CH635_RS03540 679600..679836 + 237 WP_101494098.1 hypothetical protein -
CH635_RS03545 679888..683280 + 3393 WP_116956873.1 tape measure protein -
CH635_RS03550 683289..683621 + 333 WP_038440713.1 phage tail protein -
CH635_RS09270 683713..683871 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 646856..695568 48712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T109773 WP_015701504.1 NZ_CP031679:678915-679298 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T109773 NZ_CP031679:678915-679298 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT109773 WP_005651224.1 NZ_CP031679:679282-679584 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT109773 NZ_CP031679:679282-679584 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References