Detailed information of TA system TA109746

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 890128..890466
• Replicon: chromosome
• Accession: NZ_CP031673
• Organism: Staphylococcus aureus strain MOZ66

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DD548_RS04670
• Protein ID: WP_072353918.1
• Coordinates: 890128..890304 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	890292..890466 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD548_RS04650	885295..889077	+	3783	WP_001836550.1	phage protein	-
DD548_RS04655	889070..889222	+	153	WP_001000058.1	hypothetical protein	-
DD548_RS04660	889268..889555	+	288	WP_001262620.1	hypothetical protein	-
DD548_RS04665	889611..889985	+	375	WP_000340977.1	hypothetical protein	-
DD548_RS04670	890128..890304	+	177	WP_072353918.1	putative holin-like toxin	Toxin
-	890292..890466	-	175	-	-	Antitoxin
DD548_RS04680	890516..890770	+	255	WP_000611512.1	phage holin	-
DD548_RS04685	890782..891537	+	756	WP_000861038.1	CHAP domain-containing protein	-
DD548_RS04690	891728..892219	+	492	WP_000920041.1	staphylokinase	-
DD548_RS04705	892871..893206	+	336	Protein_880	SH3 domain-containing protein	-
DD548_RS04710	893716..894066	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
DD548_RS04715	894119..894379	-	261	WP_001791826.1	hypothetical protein	-
DD548_RS04725	894690..894869	-	180	WP_000669789.1	hypothetical protein	-
DD548_RS04730	895191..895441	-	251	Protein_884	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / scn	827351..894066	66715

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T109746 WP_072353918.1 NZ_CP031673:890128-890304 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T109746 NZ_CP031673:890128-890304 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT109746 NZ_CP031673:c890466-890292 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin