Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 411368..411552 Replicon chromosome
Accession NZ_CP031673
Organism Staphylococcus aureus strain MOZ66

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag DD548_RS01960 Protein ID WP_000482650.1
Coordinates 411368..411475 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 411492..411552 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD548_RS01935 406730..407203 + 474 WP_000456489.1 GyrI-like domain-containing protein -
DD548_RS01940 407326..408537 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
DD548_RS01945 408719..409378 - 660 WP_000831298.1 membrane protein -
DD548_RS01950 409438..410580 - 1143 Protein_366 glycerate kinase -
DD548_RS01955 410848..411234 + 387 WP_000779358.1 flippase GtxA -
DD548_RS01960 411368..411475 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 411492..411552 - 61 - - Antitoxin
DD548_RS01970 412103..413866 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
DD548_RS01975 413891..415624 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
DD548_RS01985 415855..416022 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T109737 WP_000482650.1 NZ_CP031673:411368-411475 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T109737 NZ_CP031673:411368-411475 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT109737 NZ_CP031673:c411552-411492 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References