Detailed information of TA system TA109731

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2266763..2266980
• Replicon: chromosome
• Accession: NZ_CP031670
• Organism: Staphylococcus aureus strain 64

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DD547_RS11920
• Protein ID: WP_001802298.1
• Coordinates: 2266876..2266980 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2266763..2266818 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD547_RS11900	2262900..2263565	-	666	WP_001024094.1	SDR family oxidoreductase	-
DD547_RS11905	2263717..2264037	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DD547_RS11910	2264039..2265019	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
DD547_RS11915	2265285..2266376	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2266763..2266818	+	56	-	-	Antitoxin
DD547_RS11920	2266876..2266980	-	105	WP_001802298.1	hypothetical protein	Toxin
DD547_RS15250	2267141..2267624	-	484	Protein_2208	recombinase family protein	-
DD547_RS11930	2267667..2268803	-	1137	WP_000115562.1	SAP domain-containing protein	-
DD547_RS11935	2269092..2269184	+	93	WP_001790138.1	hypothetical protein	-
DD547_RS11940	2269889..2270746	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
DD547_RS11945	2270814..2271596	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T109731 WP_001802298.1 NZ_CP031670:c2266980-2266876 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T109731 NZ_CP031670:c2266980-2266876 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT109731 NZ_CP031670:2266763-2266818 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin